CAJ | 학술논문

目的：探讨外源性H2 O2对ICR鼠血脂的影响。方法腹腔注射不同的浓度的H2 O2处理ICR小鼠6周后，分光光度计法分别检测各组血清总胆固醇（ TC）、甘油三酯（ TG）及高密度脂蛋白／低密度脂蛋白比值（HDL／LDL）。结果与对照组相比，浓度为0．75％、1．5％ H2O2处理组血清TC、TG水平升高，而HDL／LDL比值降低，但差异不显著（P＞0．05）；而3％H2O2处理组血清TC、TG水平显著升高（P＜0．01），HDL／LDL比值显著降低（P＜0．01）。结论 H2O2可诱导ICR小鼠高脂血症。
목적：탐토외원성H2 O2대ICR서혈지적영향。방법복강주사불동적농도적H2 O2처리ICR소서6주후，분광광도계법분별검측각조혈청총담고순（ TC）、감유삼지（ TG）급고밀도지단백／저밀도지단백비치（HDL／LDL）。결과여대조조상비，농도위0．75％、1．5％ H2O2처리조혈청TC、TG수평승고，이HDL／LDL비치강저，단차이불현저（P＞0．05）；이3％H2O2처리조혈청TC、TG수평현저승고（P＜0．01），HDL／LDL비치현저강저（P＜0．01）。결론 H2O2가유도ICR소서고지혈증。
Objective To explore the influence of exogenous Hydrogen peroxide on serum lipids levels . Methods Administration of Hydrogen peroxide on ICR mouse with different Concentrations through intraperitoneal injection .After 6 weeks, all animals were sacrificed and serum were collected to detect the levels of TC, TG and the ratio of HDL to LDL(HDL/LDL).Results Compared with control group, increased serum levels of TC or TG and decreased ratio of HDL to LDL were seen in groups with treatment of Hydrogen peroxide at concentration of 0.75% or 1.5%( M/M), but no statistically significant difference were found among above groups, However , serum TC and TG levels were elevated ( P<0.01,vs control) and HDL/LDL was reduced (P<0.01,vs control)significantly in group treated by 3% concentration of Hydrogen peroxide .Conclusions Hydrogen peroxide induced dyslipidemia in ICR mice .