中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
3期
35-36,37
,共3页
利培酮%奥氮平%脑器质性精神障碍%精神症状
利培酮%奧氮平%腦器質性精神障礙%精神癥狀
리배동%오담평%뇌기질성정신장애%정신증상
Risperidone%Olanzapine%Brain organic mental disorder%Mental symptoms
目的：探讨利培酮联合奥氮平治疗脑器质性精神障碍的有效性和安全性，评价临床疗效。方法选择我院2011‐10—2013‐10收治的脑器质性精神障碍患者130例，分为对照组和观察组，对照组63例患者单独口服奥氮平治疗；观察组67例患者采用利培酮联合奥氮平治疗。2组患者均于治疗前及治疗后1、3、5、7周末使用阳性和阴性精神症状量表（PA N‐SS ）评定患者精神障碍的缓解情况，比较2组总有效率及不良反应发生率。结果观察组治疗后1周末即显示出明显效果，而对照组则在治疗后3周末才与入组时有显著性差异，且2组间PANSS量表评分及减分率在治疗后1、3、5、7周末差异均有统计学意义（ P＜0.01）；观察组总有效率高达95.52％，显著优于对照组的85.71％，2组对比差异有统计学意义（χ2＝12.13，P＜0.01）；2组不良反应率分别为34.33％、33.33％，差异无统计学意义（χ2＝2.26，P＞0.05）。结论利培酮联合奥氮平应用于治疗脑器质性精神障碍中，能显著缓解患者的精神症状，且不增加药物的不良反应，值得临床推广。
目的：探討利培酮聯閤奧氮平治療腦器質性精神障礙的有效性和安全性，評價臨床療效。方法選擇我院2011‐10—2013‐10收治的腦器質性精神障礙患者130例，分為對照組和觀察組，對照組63例患者單獨口服奧氮平治療；觀察組67例患者採用利培酮聯閤奧氮平治療。2組患者均于治療前及治療後1、3、5、7週末使用暘性和陰性精神癥狀量錶（PA N‐SS ）評定患者精神障礙的緩解情況，比較2組總有效率及不良反應髮生率。結果觀察組治療後1週末即顯示齣明顯效果，而對照組則在治療後3週末纔與入組時有顯著性差異，且2組間PANSS量錶評分及減分率在治療後1、3、5、7週末差異均有統計學意義（ P＜0.01）；觀察組總有效率高達95.52％，顯著優于對照組的85.71％，2組對比差異有統計學意義（χ2＝12.13，P＜0.01）；2組不良反應率分彆為34.33％、33.33％，差異無統計學意義（χ2＝2.26，P＞0.05）。結論利培酮聯閤奧氮平應用于治療腦器質性精神障礙中，能顯著緩解患者的精神癥狀，且不增加藥物的不良反應，值得臨床推廣。
목적：탐토리배동연합오담평치료뇌기질성정신장애적유효성화안전성，평개림상료효。방법선택아원2011‐10—2013‐10수치적뇌기질성정신장애환자130례，분위대조조화관찰조，대조조63례환자단독구복오담평치료；관찰조67례환자채용리배동연합오담평치료。2조환자균우치료전급치료후1、3、5、7주말사용양성화음성정신증상량표（PA N‐SS ）평정환자정신장애적완해정황，비교2조총유효솔급불량반응발생솔。결과관찰조치료후1주말즉현시출명현효과，이대조조칙재치료후3주말재여입조시유현저성차이，차2조간PANSS량표평분급감분솔재치료후1、3、5、7주말차이균유통계학의의（ P＜0.01）；관찰조총유효솔고체95.52％，현저우우대조조적85.71％，2조대비차이유통계학의의（χ2＝12.13，P＜0.01）；2조불량반응솔분별위34.33％、33.33％，차이무통계학의의（χ2＝2.26，P＞0.05）。결론리배동연합오담평응용우치료뇌기질성정신장애중，능현저완해환자적정신증상，차불증가약물적불량반응，치득림상추엄。
Objective To explore the efficacy and safety of risperidone combined with olanzapine for the treatment of brain organic mental disorders ,and evaluated the clinical efficacy. Methods Totally 130 cases patients with brain organic mental dis‐orders in our hospital from October 2011 to October 2013 and were divided into the control group and observation group. 63 pa‐tients in the control group were treated with olanzapine;while the 67 patients in the observation group were treated with risper‐idone combined with olanzapine. The positive and negative syndrome scale spirit (PANSS) was used to assess the remission of mental disorders before and after treatment for 1 ,3 ,5 ,7 weekends. The total clinical efficacy and the incidence of adverse re‐actions were compared. Results The observation group had significant efficacy after treatment for 1 weekend which was 3 weekends in the control group. And the PANSS scores and the reduced rate between the two groups of 1 ,3 ,5 ,7 weekends all showed a significant difference (P<0.01). The total clinical effective rate in the observation group was up to 95.52% ,which was significantly higher than that of 85.71% in the control group ,the difference was significant(χ2 =12.13 ,P<0.01);And the adverse reaction rates of the two groups were 34.33% ,33.33% ,which had no significant difference(χ2 =2.26 ,P>0.05) . Conclusion Risperidone combined with olanzapine for the brain organic mental disorders can significantly ease the mental symptoms ,and not increase the adverse drug reactions. It is worthy of clinical promotion.
