CAJ | 학술논문

目的：观察阿托伐他汀对急性脑梗死患者血清超敏C反应蛋白（hs‐CRP）、白细胞介素‐17（IL‐17）、基质金属蛋白酶‐8（MMP‐8）及血脂的影响。方法将76例急性脑梗死患者随机分为对照组和观察组，对照组只给予常规治疗；观察组给予常规治疗及口服阿托伐他汀片20 mg ，晚上口服，1次／d ，疗程2周。分别在确诊24 h内和治疗后观察2组患者血清超敏C反应蛋白、白细胞介素‐17、基质金属蛋白酶‐8及血脂的变化情况，并就阿托伐他汀对急性脑梗死患者的临床疗效进行评价。结果治疗2周后，观察组患者与对照组相比血清超敏C反应蛋白、白细胞介素‐17、基质金属蛋白酶‐8、总胆固醇（T C ）、甘油三酯（TG）、低密度脂蛋白（LDL‐C）显著降低，高密度脂蛋白（HDL‐C）显著升高，差异有统计学意义（P＜0.05）。结论阿托伐他汀能够降低急性脑梗死患者血清超敏C反应蛋白、白细胞介素‐17、基质金属蛋白酶‐8的水平，并对急性脑梗死患者具有良好的调脂作用，显著降低患者血脂水平从而减轻患者脑缺血性损害。
목적：관찰아탁벌타정대급성뇌경사환자혈청초민C반응단백（hs‐CRP）、백세포개소‐17（IL‐17）、기질금속단백매‐8（MMP‐8）급혈지적영향。방법장76례급성뇌경사환자수궤분위대조조화관찰조，대조조지급여상규치료；관찰조급여상규치료급구복아탁벌타정편20 mg ，만상구복，1차／d ，료정2주。분별재학진24 h내화치료후관찰2조환자혈청초민C반응단백、백세포개소‐17、기질금속단백매‐8급혈지적변화정황，병취아탁벌타정대급성뇌경사환자적림상료효진행평개。결과치료2주후，관찰조환자여대조조상비혈청초민C반응단백、백세포개소‐17、기질금속단백매‐8、총담고순（T C ）、감유삼지（TG）、저밀도지단백（LDL‐C）현저강저，고밀도지단백（HDL‐C）현저승고，차이유통계학의의（P＜0.05）。결론아탁벌타정능구강저급성뇌경사환자혈청초민C반응단백、백세포개소‐17、기질금속단백매‐8적수평，병대급성뇌경사환자구유량호적조지작용，현저강저환자혈지수평종이감경환자뇌결혈성손해。
Objective To observe the effect of atorvastatin on serum hypersensitive C‐reactive protein, interleukin‐17 and matrix metalloproteinases‐8 and blood lipid levels in patients with acute cerebral infarction .Methods Totally 76 cases of pa‐tients with acute cerebral infarction were randomly divided into control group and observation group, control group was given conventional treatment ;observation group was given conventional treatment and atorvastatin, oral 20 mg at night, once a day ;treatment course was both 2 weeks .The levels of hypersensitive C‐reactive protein, serum interleukin‐17, matrix metallopro‐teinases‐8 and blood lipid were diagnosed within 24h and after treatment, and the clinical efficacy of patients with acute cerebral infarction was evaluated .Results 2 weeks after treatment, compared with control group, serum hypersensitive C‐reactive pro‐tein, interleukin‐17, matrix metalloproteinases‐8, total cholesterol (TC), triglycerides (TG), low‐density lipoprotein (LDL‐C) of the observation group were significantly reduced, high‐density lipoprotein (HDL‐C) was significantly elevated (P<0.05) .Conclusion The levels of serum hypersensitive C‐reactive protein, interleukin 17, matrix metalloproteinases‐8, blood lipid and the patients with cerebral ischemic damage were reduced by using atorvastatin, and the clinical effect was significant .