CAJ | 학술논문

目的：分析不同TOAST分型青年脑梗死与高同型半胱氨酸血症的相关性，为临床病因诊断提供依据。方法选取本院近3 a 收治的青年脑梗死患者为研究组，另选取同期在我院体检的健康体检者136例为对照组，按TOAST 分型对136例青年脑梗死患者进行分组，采用循环酶法技术测定血浆Hcy 水平，使用NIHSS 量表评分。结果同对照组相比，青年脑梗死患者血清Hcy 水平显著升高（P＜0.05），在TOAST 分型中LAA 型血清Hcy 水平和NIHSS 评分与其他4个亚型比较差异有统计学意义（P＜0.05），其他4个亚型（SAA 、CA 、SOE 、SUE）组间比较差异无统计学意义（ P ＞0.05）。结论脑梗死病因常与动脉粥样硬化有关，LAA 型发病后病情程度往往较其他亚型重，应重视早期干预和治疗。
목적：분석불동TOAST분형청년뇌경사여고동형반광안산혈증적상관성，위림상병인진단제공의거。방법선취본원근3 a 수치적청년뇌경사환자위연구조，령선취동기재아원체검적건강체검자136례위대조조，안TOAST 분형대136례청년뇌경사환자진행분조，채용순배매법기술측정혈장Hcy 수평，사용NIHSS 량표평분。결과동대조조상비，청년뇌경사환자혈청Hcy 수평현저승고（P＜0.05），재TOAST 분형중LAA 형혈청Hcy 수평화NIHSS 평분여기타4개아형비교차이유통계학의의（P＜0.05），기타4개아형（SAA 、CA 、SOE 、SUE）조간비교차이무통계학의의（ P ＞0.05）。결론뇌경사병인상여동맥죽양경화유관，LAA 형발병후병정정도왕왕교기타아형중，응중시조기간예화치료。
Objective To analyze the correlation between different TOAST classification youth infarction and high homo‐cysteine ,and provide the basis for clinical diagnosis.Methods Totally 136 youth patients with cerebral infarction nearly three years were selected as observation group ,and 136 youth healthy subjects in the same period were selected as control group.Observation group was grouped by TOAST classification.Plasma Hcy levels and NIHSS score were analyzed and com‐pared.Results Serum Hcy levels in young patients with cerebral infarction were higher than those of control group ( P<0.05) ,the serum Hcy levels and NIHSS score of LAA TOAST type were statistically significant different from the other four subtypes (P<0.05) ,while the other four subtypes(SAA ,CA ,SOE ,SUE) had no statistically significant differences.Conclusion The etiology of cerebral infarction is often related to atherosclerosis.The disease severity of LAA type is heavier than the other four subtypes.We should pay attention to early intervention and treatment.