CAJ | 학술논문

目的：探讨DNA免疫吸附治疗重症系统性红斑狼疮（ SLE）的临床有效性、安全性。方法：收集重症SLE患者20例，分为观察组（8例）和对照组（12例）。观察组采用连续性血液净化联合DNA免疫吸附配合泼尼松片、环磷酰胺治疗，对照组采用甲强龙冲击后，给予泼尼松片联合环磷酰胺治疗。比较2组患者治疗前及治疗12周、24周SLEDAI评分及ANA、抗ds－DNA抗体滴度，IgG，IgA，IgM，C3，C4，肾功能等指标。结果：与对照组比较，治疗12周观察组SLEDAI评分、ANA与抗ds－DNA抗体滴度下降更快（ P均＜0．05），24周时观察组ANA滴度仍能维持在较低水平（ P均＜0．05）。治疗24周，2组患者肾功能均稳定。观察组除1例发生重症感染，无精神异常、心律失常等不良反应发生。结论：DNA免疫吸附治疗重症SLE安全、有效。
목적：탐토DNA면역흡부치료중증계통성홍반랑창（ SLE）적림상유효성、안전성。방법：수집중증SLE환자20례，분위관찰조（8례）화대조조（12례）。관찰조채용련속성혈액정화연합DNA면역흡부배합발니송편、배린선알치료，대조조채용갑강룡충격후，급여발니송편연합배린선알치료。비교2조환자치료전급치료12주、24주SLEDAI평분급ANA、항ds－DNA항체적도，IgG，IgA，IgM，C3，C4，신공능등지표。결과：여대조조비교，치료12주관찰조SLEDAI평분、ANA여항ds－DNA항체적도하강경쾌（ P균＜0．05），24주시관찰조ANA적도잉능유지재교저수평（ P균＜0．05）。치료24주，2조환자신공능균은정。관찰조제1례발생중증감염，무정신이상、심률실상등불량반응발생。결론：DNA면역흡부치료중증SLE안전、유효。
Aim:To investigate the clinical efficacy and safety of DNA immunoadsorption on patients with severe sys -temic lupus erythematosus ( SLE). Methods: Twenty cases of severe SLE were allocated into 2 groups; observation group (n=8) received continuous blood purification, DNA immunoadsorption and glucocorticoid treatment ,and control group ( n=12 ) received cyclophosphamide combined with glucocorticoid treatment. Before and at 12 and 24 weeks after the ther-apy, SLEDAI score, autoantibodies(ANA) and anti-ds DNA autoantibody titer, IgG, IgA, IgM levels, C3 and C4 and re-nal function parameters were assessed. Results:At 12 weeks after the treatment, the SLEDAI score, ANA and anti-dsD-NA autoantibody titer in the observation group decreased more significantly than control group ;at 24 weeks after the treat-ment, the ANA titer in the observation group still maintained in a low level (P<0.05).The renal function were stable in two groups during 24 weeks. There were no obvious side effects except for a case of severe infection. Conclusion:DNA immunoadsorption in treatment of severe SLE is effective and safe.