CAJ | 학술논문

目的：探讨舌鳞状细胞癌（Tongue squamous cell carcinoma，TSCC）组织中分化抑制因子－1（Inhibitor of dif－ferentiation－1，Id－1）和乏氧诱导因子－1α（Hypoxia－inducible factor－1α，HIF－1α）的表达及与微血管密度（microvessel density，MVD）的关系。方法：应用免疫组织化学SP法检测65例TSCC中Id－1，HIF－1α，CD34的表达并计数MVD。结果：65例TSCC中Id－1有34例（52．3﹪）阳性表达，43例HIF－1α（66．2﹪）阳性表达。 Id－1和HIF－1α表达与TSCC病理分级，淋巴结转移及TNM分期显著相关（P＜0．05，χ2检验），并且与MVD值相关（P＜0．05）。在TSCC中Id－1和HIF－1α表达呈正相关（P＜0．05）。结论：Id－1和HIF－1α与TSCC的恶性进展密切相关，共同参与肿瘤血管生成的过程。联合检测可作为判断TSCC恶性潜能的重要生物指标。
목적：탐토설린상세포암（Tongue squamous cell carcinoma，TSCC）조직중분화억제인자－1（Inhibitor of dif－ferentiation－1，Id－1）화핍양유도인자－1α（Hypoxia－inducible factor－1α，HIF－1α）적표체급여미혈관밀도（microvessel density，MVD）적관계。방법：응용면역조직화학SP법검측65례TSCC중Id－1，HIF－1α，CD34적표체병계수MVD。결과：65례TSCC중Id－1유34례（52．3﹪）양성표체，43례HIF－1α（66．2﹪）양성표체。 Id－1화HIF－1α표체여TSCC병리분급，림파결전이급TNM분기현저상관（P＜0．05，χ2검험），병차여MVD치상관（P＜0．05）。재TSCC중Id－1화HIF－1α표체정정상관（P＜0．05）。결론：Id－1화HIF－1α여TSCC적악성진전밀절상관，공동삼여종류혈관생성적과정。연합검측가작위판단TSCC악성잠능적중요생물지표。
Objective:To investigate the correlation between the expression of inhibitor of differentiation-1(Id-1) and Hypoxia-inducible factor-1 (HIF-1α) and microvessel density (MVD) in Tongue squamous cell carcinoma (TSCC). Method:Id-1 and HIF-1α expression were investigated by means of immunohistochemistry in samples from 65 cases of TSCC.The density of the microvessels immunohistochemically stained by CD34 antibody,respectively,was calculated. Result:Id-1 positive expression occurred in 34 out of the 65 tumor samples (52.3 %),while HIF-1α positive expression was ob-served in 43 out of the 65 tumor samples(66.3%).The positive expression of Id-1 and HIF-1αwere significantly associated with pathological grad,lymph node metastasis and TNM stage (P<0.05,Chi-square test).TSCC with positive Id-1 and HIF-1αexpression have higher MVD(P<0.05,Mann-Whitney U-test). There were positive corelations between the expression of Id-1 and HIF-1α(P<0.05,Chi-square test). Conclusion:Id-1 and HIF-1αtake part in the malignant progression and an-giogenesis of TSCC.They can be considered as biological indicators of malignant potential in TSCC.