CAJ | 학술논문

目的：研究高温高压后的壳聚糖／甘油磷酸钠凝胶温敏、释药性能。方法：观察不同比例的壳聚糖和甘油磷酸钠混合液的凝胶时间、pH值变化。粘度测试比较不同比例壳聚糖／甘油磷酸钠混合液粘度变化。在37℃形成凝胶后，观察该体系作为奥硝唑药物模型载体的释药性能。结果：随着壳聚糖／甘油磷酸钠混合液中甘油磷酸钠的比例增加，溶液pH值增加，在37℃下，壳聚糖／甘油磷酸钠凝胶时间缩短，但当壳聚糖／甘油磷酸比例为2：1、1：1时，溶液不凝胶。粘度实验表明，4种比例（9：1、8：1、7：1、6：1）壳聚糖／甘油磷酸溶液随着时间增加，粘度明显增加，到10 min后粘度基本不变化，9：1比例组粘度最大为（53±0．9）Pa·s。药物释放实验表明，以奥硝唑为释药模型，该凝胶可持续释放200 min以上。结论：改进消毒方法后的壳聚糖／甘油磷酸钠，增加甘油磷酸钠比例可以提高溶液pH值，可在37℃下快速形成凝胶。该凝胶具有温敏性，具有缓慢释放药物能力。
목적：연구고온고압후적각취당／감유린산납응효온민、석약성능。방법：관찰불동비례적각취당화감유린산납혼합액적응효시간、pH치변화。점도측시비교불동비례각취당／감유린산납혼합액점도변화。재37℃형성응효후，관찰해체계작위오초서약물모형재체적석약성능。결과：수착각취당／감유린산납혼합액중감유린산납적비례증가，용액pH치증가，재37℃하，각취당／감유린산납응효시간축단，단당각취당／감유린산비례위2：1、1：1시，용액불응효。점도실험표명，4충비례（9：1、8：1、7：1、6：1）각취당／감유린산용액수착시간증가，점도명현증가，도10 min후점도기본불변화，9：1비례조점도최대위（53±0．9）Pa·s。약물석방실험표명，이오초서위석약모형，해응효가지속석방200 min이상。결론：개진소독방법후적각취당／감유린산납，증가감유린산납비례가이제고용액pH치，가재37℃하쾌속형성응효。해응효구유온민성，구유완만석방약물능력。
Objective:To investigate thermosensitivity and drug release of chitosan/glycerphosphate (CS/GPS) by improved method of sterilization. Method:The gel time,viscosity and pH of different proportion of CS/GPS solution were investigated. The drug release of the gel formed at 37℃was evaluated by Ornidazole as a model drug. Result:The more the ratio of glycerophosphate in CS/GPS was,the higher the pH of CS/GPS was,and the shorter the gel time was at 37℃. But when the ratio of CS/GPS was 2:1 and 1:1,the solution didn't form gel. The viscosity experiment showed that As the time increased,the viscosity of four proportions (9:1,8:1,7:1,6:1) CS/GPS solution increased distinctly. The viscosity didn't change at 10 min,the proportion of 9:1 was highest at (53±0.9)Pa·s. Drug release experiment showed that using ornidazole as release model,the gel could release over 200min. Conclusion:when CS/GPS was sterilized by improved method,in-creased the ratio of GPS could raise the pH of CS/GPS and rapidly formed gel at 37℃. The gel had thermositivity and sus-tained capacity of release drug.