CAJ | 학술논문

目的：探讨长期配戴硬性角膜接触镜对泪膜稳定性的影响。方法选取80例(160眼)患者分成四组：硬性角膜接触镜( RGP组)：长期配戴RGP (20例,40眼)；角膜塑形镜组：长期夜间配戴角膜塑形镜(22例,44眼)；软性接触镜组：长期配戴软性接触镜(20例,40眼)；对照组：为无角膜接触镜配戴史的低度近视患者(18例,36眼),分别在戴镜前和戴镜后1个月、6个月、1年、2年检测视力,施墨(Schirmer I)试验检测泪腺分泌功能,泪膜破裂时间( BUT)测定泪膜破裂时间,结膜印迹细胞学( CIC)观察结膜表层细胞形态学改变及结膜杯状细胞数目,泪膜羊齿状实验评估泪液中蛋白质含量的变化,观察结果进行统计学分析。结果各实验组的泪腺分泌功能和泪膜破裂时间均降低,与对照组间比较差异有统计学意义(P<0.05),各实验组长期持续配戴角膜接触镜后结膜杯状细胞减少,且不能形成良好的蕨样变现象。结论长期配戴角膜接触镜可致泪膜稳定性下降,泪液分泌量减少。
목적：탐토장기배대경성각막접촉경대루막은정성적영향。방법선취80례(160안)환자분성사조：경성각막접촉경( RGP조)：장기배대RGP (20례,40안)；각막소형경조：장기야간배대각막소형경(22례,44안)；연성접촉경조：장기배대연성접촉경(20례,40안)；대조조：위무각막접촉경배대사적저도근시환자(18례,36안),분별재대경전화대경후1개월、6개월、1년、2년검측시력,시묵(Schirmer I)시험검측루선분비공능,루막파렬시간( BUT)측정루막파렬시간,결막인적세포학( CIC)관찰결막표층세포형태학개변급결막배상세포수목,루막양치상실험평고루액중단백질함량적변화,관찰결과진행통계학분석。결과각실험조적루선분비공능화루막파렬시간균강저,여대조조간비교차이유통계학의의(P<0.05),각실험조장기지속배대각막접촉경후결막배상세포감소,차불능형성량호적궐양변현상。결론장기배대각막접촉경가치루막은정성하강,루액분비량감소。
Objective To investigate the effect of long-term wearing rigid contact lenses on the stability of tear film. Methods Eighty ( one hundred sixty eyes) patients were randomly divided into four groups:Group one,Long-term wearing RGP ( twenty patients,forty eyes);Group two,Long-term wearing orthokeratology lenses at night ( twenty-two patients,forty-four eyes);Group three,Long-term wearing soft contact lenses ( twenty patients,forty eyes); Normal control,low myopia patients without a history of wearing contact lenses (eighteen patients,thirty-six eyes). Patients’ vision,Schirmer I test, break-up time ( BUT) of tear film,conjunctival impression cytology ( CIC) ,and tear film fern experiments were performed before wearing lenses,wearing for one month,wearing for six month,wearing for one year,wearing for two years,respective-ly. Results The results of Schirmer I test and break-up time ( BUT) of tear film in each experimental group were re-duced as compared with normal control group. The difference was statistically significant (P<0. 05). After long-term wear-ing contact lenses,the conjunctival goblet cells was decreased in all experimental groups,and can not form a good ferning phenomenon. Conclusions Long-term wearing contact lenses can result in decreasing the stability of tear film and re-duce tear secretion.