CAJ | 학술논문

目的：探讨血清PCT、CRP水平对脓毒症的诊断及预后评估的价值。方法回顾分析2012年7月~2013年5月入住本院EICU的危重患者120例，其中脓毒症患者63例，非脓毒症患者57例作为对照。脓毒症患者根据预后情况分为生存组和死亡组，分析各组的血清PCT和CRP水平。结果脓毒症组血清PCT和CRP水平以及APACHEⅡ评分和SOFA评分均显著大于非脓毒症组(P<0.05)；血清PCT诊断脓毒症的敏感性、特异性、阳性预测值和阴性预测值均明显大于血清CRP(P<0.05)；生存组的血清PCT和CRP值在第1、3、5、7天均显著地小于死亡组(P<0.05)，并有显著的时间效应(P<0.05)，但在死亡组却无显著的时间效应(P>0.05)。结论血清PCT和CRP是诊断脓毒症和评估预后的可靠指标，并且血清PCT敏感性和特异性高于血清CRP。
목적：탐토혈청PCT、CRP수평대농독증적진단급예후평고적개치。방법회고분석2012년7월~2013년5월입주본원EICU적위중환자120례，기중농독증환자63례，비농독증환자57례작위대조。농독증환자근거예후정황분위생존조화사망조，분석각조적혈청PCT화CRP수평。결과농독증조혈청PCT화CRP수평이급APACHEⅡ평분화SOFA평분균현저대우비농독증조(P<0.05)；혈청PCT진단농독증적민감성、특이성、양성예측치화음성예측치균명현대우혈청CRP(P<0.05)；생존조적혈청PCT화CRP치재제1、3、5、7천균현저지소우사망조(P<0.05)，병유현저적시간효응(P<0.05)，단재사망조각무현저적시간효응(P>0.05)。결론혈청PCT화CRP시진단농독증화평고예후적가고지표，병차혈청PCT민감성화특이성고우혈청CRP。
Objective To explore the diagnostic and prognosis-evaluted value of serum procal citonin ( PCT) and C-reactive protein (CRP) on sepsis. Methods A total of 120 patients in our hospital EICU from July 2012 to May 2013, including 63 cases of sepsis ( sepsis group) and 57 cases of cases of non-sepsis ( non-sepsis group) were tested the levels of serum PCT and CRP. Sepsis patients were divided into survival group and death group according the prognosis. Results The levels of serum PCT and CRP,as well as acute physiology and chronic health evaluationⅡ ( APACHEⅡ) scores and sepsis related organ failure assessment ( SOFA) scores in the sepsis group were significantly larger than those in the non-sepsis and control groups (P<0. 05). The sensitivity,specificity,positive predictive value,and negative predictive value for serum PCT in diagnosing sepsis were significantly larger than those for serum CRP (P<0. 05). The levels of serum PCT and CRP in survival group were less than those in death group on the 1,3,5,and 7 days (P< 0. 05). Moreover,there was significant time effects on level of serum PCT1 and CRP in survival group (P< 0. 05),but not in death group (P>0. 05). Conclusions The levels of serum PCT and CRP are reliability indexes for in diagnosing sepsis and evalua-ting prognosis. Moreover the sensitivity and specificity of serum PCT were better those of serum CRP.