CAJ | 학술논문

目的：对比研究监测急性冠状动脉综合征患者氯吡格雷疗效的两种方法：血栓弹力图法（TEG）与光学比浊法（LTA）。方法用 LTA法与TEG法检测2013年2月～12月期间心内科68例急性冠状动脉综合征患者的血小板聚集功能，并对两种方法的检测结果进行比较。结果 TEG监测的血小板抑制率为（47.84±26.04）％，LTA监测的血小板聚集率为（45.64±20.92）％。患者组中 LTAADP与TEGADP存在负相关（r＝－0.752，P＜0.001）；LTAADP与 MAADP存在正相关（r＝0.789，P＜0.001）；TEGADP与 MAADP呈负相关（r＝－0.820，P＜0.001）。结论 TEG血小板图与 LTA监测氯吡格雷疗效具有较好的相关性。用 MAADP联合TEGADP监测氯吡格雷抗血小板治疗效果，可提供更高的临床预测价值。
목적：대비연구감측급성관상동맥종합정환자록필격뢰료효적량충방법：혈전탄력도법（TEG）여광학비탁법（LTA）。방법용 LTA법여TEG법검측2013년2월～12월기간심내과68례급성관상동맥종합정환자적혈소판취집공능，병대량충방법적검측결과진행비교。결과 TEG감측적혈소판억제솔위（47.84±26.04）％，LTA감측적혈소판취집솔위（45.64±20.92）％。환자조중 LTAADP여TEGADP존재부상관（r＝－0.752，P＜0.001）；LTAADP여 MAADP존재정상관（r＝0.789，P＜0.001）；TEGADP여 MAADP정부상관（r＝－0.820，P＜0.001）。결론 TEG혈소판도여 LTA감측록필격뢰료효구유교호적상관성。용 MAADP연합TEGADP감측록필격뢰항혈소판치료효과，가제공경고적림상예측개치。
Objective To comparatively study the difference between thromboelastography (TEG)and light transmission ag-gregometry (LTA)in monitoring clopidogrel effect in patients with acute coronary syndrome.Methods 68 patients with a-cute coronary syndrome,who were in hospital from February to December 2013,were enrolled in this study.They received TEG and LTA to determine platelet aggregation.Results Clopidogrel effect was (47.84±26.04)% and (45.64±20.92)%respectively by TEG and LTA.There were negative correlation between LTAADP and TEGADP(r=-0.752,P<0.001),pos-itive correlation between LTAADP and MAADP(r=0.789,P<0.001),negative correlation between TEGADP and MAADP(r=-0.820,P<0.001).Conclusion There was a good correlation between the two methods.TEG can be used to evaluate thera-peutic effect of Clopidogrel effect.