CAJ | 학술논문

目的：探讨乳腺癌患者手术及化疗后淋巴细胞亚群数值变化及临床意义。方法选择2011年入住医院的25例病理确诊为乳腺癌且接受了手术及化疗的患者，用流式细胞仪测定其外周血 CD3＋，CD4＋，CD8＋，CD4＋／CD8＋及 NK细胞不同治疗时期的数值，统计学比较治疗前及治疗后不同期间 T细胞亚群及 NK细胞的变化，对结果进行对比分析。结果患者治疗1～3个月，CD8＋显著性降低（t＝2.57）；治疗3～6月，NK 细胞显著性升高（t＝－2.23）；治疗6个月后CD3＋（t＝－2.25），CD4＋（t＝－2.07）显著性降低，NK细胞显著性升高（t＝－3.56）。其余变化无统计学意义。结论乳腺癌患者T细胞亚群及 NK细胞能一定程度地反映患者治疗中的免疫状况，但治疗中具体数值的变化对治疗效果的评价以及预后判断的临床意义需进一步探讨。
목적：탐토유선암환자수술급화료후림파세포아군수치변화급림상의의。방법선택2011년입주의원적25례병리학진위유선암차접수료수술급화료적환자，용류식세포의측정기외주혈 CD3＋，CD4＋，CD8＋，CD4＋／CD8＋급 NK세포불동치료시기적수치，통계학비교치료전급치료후불동기간 T세포아군급 NK세포적변화，대결과진행대비분석。결과환자치료1～3개월，CD8＋현저성강저（t＝2.57）；치료3～6월，NK 세포현저성승고（t＝－2.23）；치료6개월후CD3＋（t＝－2.25），CD4＋（t＝－2.07）현저성강저，NK세포현저성승고（t＝－3.56）。기여변화무통계학의의。결론유선암환자T세포아군급 NK세포능일정정도지반영환자치료중적면역상황，단치료중구체수치적변화대치료효과적평개이급예후판단적림상의의수진일보탐토。
Objective To investigate the changes of lymphocyte subsets before and after the treatment with operation and chemotherapy in patients with breast cancer.Methods Using cytometer to measure lymphocyte subsets of CD3+,CD4+, CD8+,CD4+/CD8+ and NK of 25 breast cancer patients before and after treatment.The all 25 patients were treated with operation and chemotherapy after pathological diagnosis.The article compared the figures of T cell subsets before and after treatment.Results Compared with before operation and chemotherapy,the CD8+ statistically decreased after 1~3 months of treatment (t=2.57),and NK statistically increased after 3~6 (t=-2.23).After 6 months of treatment,the patients’ CD3+(t=-2.25),CD4+(t=-2.07)were statistically lower and NK (t=-3.56)was statistically higher.There was no significant difference for other items.Conclusion Lymphocyte subsets test against breast cancer patients can reflect immuni-ty level at a certain level during treatment.But how to explain the figures in different stage against treatment effectiveness and prognosis need further research.