CAJ | 학술논문

糖尿病日渐成为了当今仅次于心脑血管病和肿瘤的第三类高度威胁人类健康的疾病，研究证明外周血中存在的微小RNA（microRNA，miRNA）与糖尿病的发生与发展密切相关。由于循环 miRNA检测具有无创性、可重复性等自身特性，决定其对各类糖尿病的诊断和预后评估具有广阔的应用前景。该文初步介绍循环 miRNA的来源与特性，特别是国内外研究循环miRNA作为糖尿病诊断标志物的进展，为进一步深入研究奠定基础。
당뇨병일점성위료당금부차우심뇌혈관병화종류적제삼류고도위협인류건강적질병，연구증명외주혈중존재적미소RNA（microRNA，miRNA）여당뇨병적발생여발전밀절상관。유우순배 miRNA검측구유무창성、가중복성등자신특성，결정기대각류당뇨병적진단화예후평고구유엄활적응용전경。해문초보개소순배 miRNA적래원여특성，특별시국내외연구순배miRNA작위당뇨병진단표지물적진전，위진일보심입연구전정기출。
Diabetes mellitus has become the third threaten diseases second only to cardiovascular disease and tumor.Many re-searches demonstrated that the microRNAs(miRNAs)in blood related to the occurrence and development of diabetes melli-tus.Because of the non-invasion and repeatability of circulating miRNAs,the circulating miRNAs have a broad application prospect of diagnosis and prognosis evaluation for various types of diabetes.This overview arms to introduce the source and characters of circulating miRNA,and also the progress of circulating miRNA related to diabetes mellitus,so as to lay a foun-dation for further research.