现代检验医学杂志
現代檢驗醫學雜誌
현대검험의학잡지
JOURNAL OF MODERN LABORATORY MEDICINE
2014年
6期
142-144
,共3页
高尔基体蛋白-73%慢性乙型肝炎%肝硬化%肝纤维化
高爾基體蛋白-73%慢性乙型肝炎%肝硬化%肝纖維化
고이기체단백-73%만성을형간염%간경화%간섬유화
golgi protein 73%chronic hepatitis B%liver cirrhosis%liver fibrosis
目的：探讨乙型肝炎肝硬化患者血清中高尔基体蛋白-73（GP73）的水平与相关肝纤维化指标的关系及其临床应用价值。方法选择11例急性乙型肝炎（AHB）患者、31例慢性乙型肝炎（CHB）患者、71例乙型肝炎肝硬化（LC）患者、23例肝癌（PHC）患者和34例健康体检者作为研究对象，采用 ELISA定量检测其血清中 GP73水平，采用放射免疫法检测血清中Ⅳ型前胶原（Ⅳ-C）、透明质酸（HA）水平，同时观察 GP73与相关肝纤维化指标的关系及临床动态变化。结果 CHB组、LC组和PHC组血清GP73水平（μg／L）分别为118.0±82.2，154.4±87.7和196.5±89.6，与正常对照组比较，差异有统计学意义（t值分别为－7.284，－7.909，－9.609，P均＜0.01）；随着肝硬化的进展，血清 GP73，Ⅳ-C和 HA水平逐渐升高，且 GP73与Ⅳ-C和 HA呈明显正相关（r值分别为－0.212，0.487，P＜0.01）。结论 GP73在慢性肝病尤其是乙肝肝硬化中表达明显升高，GP73可能与乙肝肝纤维化的发生有明显的相关性，可作为判断肝纤维化程度的一个较好监测指标。
目的：探討乙型肝炎肝硬化患者血清中高爾基體蛋白-73（GP73）的水平與相關肝纖維化指標的關繫及其臨床應用價值。方法選擇11例急性乙型肝炎（AHB）患者、31例慢性乙型肝炎（CHB）患者、71例乙型肝炎肝硬化（LC）患者、23例肝癌（PHC）患者和34例健康體檢者作為研究對象，採用 ELISA定量檢測其血清中 GP73水平，採用放射免疫法檢測血清中Ⅳ型前膠原（Ⅳ-C）、透明質痠（HA）水平，同時觀察 GP73與相關肝纖維化指標的關繫及臨床動態變化。結果 CHB組、LC組和PHC組血清GP73水平（μg／L）分彆為118.0±82.2，154.4±87.7和196.5±89.6，與正常對照組比較，差異有統計學意義（t值分彆為－7.284，－7.909，－9.609，P均＜0.01）；隨著肝硬化的進展，血清 GP73，Ⅳ-C和 HA水平逐漸升高，且 GP73與Ⅳ-C和 HA呈明顯正相關（r值分彆為－0.212，0.487，P＜0.01）。結論 GP73在慢性肝病尤其是乙肝肝硬化中錶達明顯升高，GP73可能與乙肝肝纖維化的髮生有明顯的相關性，可作為判斷肝纖維化程度的一箇較好鑑測指標。
목적：탐토을형간염간경화환자혈청중고이기체단백-73（GP73）적수평여상관간섬유화지표적관계급기림상응용개치。방법선택11례급성을형간염（AHB）환자、31례만성을형간염（CHB）환자、71례을형간염간경화（LC）환자、23례간암（PHC）환자화34례건강체검자작위연구대상，채용 ELISA정량검측기혈청중 GP73수평，채용방사면역법검측혈청중Ⅳ형전효원（Ⅳ-C）、투명질산（HA）수평，동시관찰 GP73여상관간섬유화지표적관계급림상동태변화。결과 CHB조、LC조화PHC조혈청GP73수평（μg／L）분별위118.0±82.2，154.4±87.7화196.5±89.6，여정상대조조비교，차이유통계학의의（t치분별위－7.284，－7.909，－9.609，P균＜0.01）；수착간경화적진전，혈청 GP73，Ⅳ-C화 HA수평축점승고，차 GP73여Ⅳ-C화 HA정명현정상관（r치분별위－0.212，0.487，P＜0.01）。결론 GP73재만성간병우기시을간간경화중표체명현승고，GP73가능여을간간섬유화적발생유명현적상관성，가작위판단간섬유화정도적일개교호감측지표。
Objective To investigate the relationship between serum Golgi protein-73 (GP73)level and related indexes of he-patic fibrosis in patients with hepatitis B cirrhosis diseases and discuss the clinical value of GP73.Methods The level of GP73 was detected by ELISA;the levels of type Ⅳ precollagen (Ⅳ-C)and hyaluronic acid (HA)were measured by radio-immunity in serum from 11 patients with acute hepatitis B (AHB),31 patients with chronic hepatitis B (CHB),71 patients with Hepatitis B Cirrhosis (LC),23 patients with primary hepatic carcinoma (PHC)and 34 healthy people with check-up. The clinical changes and relationship between the GP-73 level and the parameter of fibrous degeneration were studied.Re-sults The GP73 level in CHB group was 118.0±82.2μg/L;the GP73 level in LC group was 154.4±87.7μg/L and the GP73 level in PHC group was 196.5±89.6μg/L.Compared with the normal control group,statistically significant differ-ence were found in GP73 level of CHB group,LC group and PHC group (t values were -7.284,-7.909 and -9.609,re-spectively;P<0.01).As the progress of liver cirrhosis,the levels of GP73,Ⅳ-C and HA all increased gradually and the level of GP73 was significantly positively correlated to Ⅳ-C and HA (r valves were -0.212 and 0.487,respectively;P<0.01). Conclusion The GP73 was high expressed in chronic liver disease,especially in liver cirrhosis.The GP73 was significantly associated with the occurrence of hepatitis b liver fibrosis.There fore,GP73 could be used as a better index to monitor the fi-brosis degree.
