CAJ | 학술논문

目的：评价血清骨桥蛋白（osteopontin，OPN）对卵巢癌的诊断价值。方法检索万方、维普和清华同方2014年5月以前发表的关于血清 OPN诊断卵巢癌的文献。以 QUADAS工具对文献进行质量评价，通过随机效应模型分析血清OPN诊断卵巢癌的总体敏感度、特异度、阳／阴性似然比和诊断优势比。以 SROC曲线法分析血清 OPN诊断卵巢癌的总体性能。结果该次meta分析共纳入6项研究，血清 OPN诊断卵巢癌的总体诊断敏感度为0.83（95％可信区间：0.78～0.87），总体诊断特异度为0.91（95％可信区间：0.88～0.94），总体诊断阳性似然比为9.00（95％可信区间：5.91～13.71），总体诊断阴性似然比为0.19（95％可信区间：0.15～0.25），总体诊断优势比为47.58（95％可信区间：27.93～81.05）。SROC曲线下面积为0.87，Q值为0.80。结论血清 OPN对卵巢癌具有较高的诊断价值。
목적：평개혈청골교단백（osteopontin，OPN）대란소암적진단개치。방법검색만방、유보화청화동방2014년5월이전발표적관우혈청 OPN진단란소암적문헌。이 QUADAS공구대문헌진행질량평개，통과수궤효응모형분석혈청OPN진단란소암적총체민감도、특이도、양／음성사연비화진단우세비。이 SROC곡선법분석혈청 OPN진단란소암적총체성능。결과해차meta분석공납입6항연구，혈청 OPN진단란소암적총체진단민감도위0.83（95％가신구간：0.78～0.87），총체진단특이도위0.91（95％가신구간：0.88～0.94），총체진단양성사연비위9.00（95％가신구간：5.91～13.71），총체진단음성사연비위0.19（95％가신구간：0.15～0.25），총체진단우세비위47.58（95％가신구간：27.93～81.05）。SROC곡선하면적위0.87，Q치위0.80。결론혈청 OPN대란소암구유교고적진단개치。
Objective To evaluate the diagnostic performance of osteopontin (OPN)for ovarian cancer.Methods Wanfang, CQVIP and CNKI were retrieved to identify eligible studies on diagnostic value of OPN for ovarian cancer that published be-fore May,2014.The quality of the studies was evaluated by QUADAS tools.The diagnostic sensitivity,specificity,negative and positive likelihood ratios and diagnostic odds ratio (DOR)were pooled by random-effects models.The overall diagnostic performance was estimated by summary receiver operating characteristic (SROC)curves approaches.Results Six studies met the included criteria.The summary estimates for OPN in the diagnosis of ovarian cancer in the studies included were as follows:sensitivity 0.83 [(95% confidence interval(CI):0.78~0.87)],specificity 0.91 (95% CI,0.88~0.94),positive likelihood ratio 9.00 (95% CI,5.91~13.71),negative likelihood ratio 0.19 (95% CI,0.15~0.25),and DOR 47.58 (95%CI,27.93~81.05).The area under curve (AUC)for OPN was 0.87 with Q value of 0.80.Conclusion OPN has high diag-nostic value for ovarian cancer.