CAJ | 학술논문

目的：研究中老年人群不同性别之间血清骨钙素水平是否存在差异，以及骨钙素水平与骨质疏松指标、其它骨代谢指标是否存在相关性。方法选取2011年1～8月中老年健康体检者270名，排除恶性肿瘤及慢性基础性疾病，其中男性101例，年龄50～89岁，中位年龄68岁，女性169例，年龄50～89岁，中位年龄64岁。使用骨密度仪进行骨密度检测，检测指标为T值；分别进行血清标本中骨钙素、25-羟维生素D、钙和磷检测。不同性别之间骨钙素水平的比较采用 Mann-Whitney检验，将骨钙素水平与骨质疏松风险指数、年龄、钙、磷和25-羟维生素 D的相关性进行 Spearman秩相关分析，P＜0.05为差异有统计学意义。结果270例中老年健康体检者的T值、骨钙素、25-羟维生素D、钙和磷水平范围分别为－3.5～－0.7（中位水平－1.6 ng／ml），3.59～264.90 ng／ml（中位水平12.84 ng／ml），4.0～34.0 ng／ml（中位水平10.5 ng／ml），1.79～2.69 mmol／L（中位水平2.36 ng／ml），0.43～2.89 mmol／L（中位水平1.12 ng／ml）；不同性别之间骨钙素存在差异，女性水平显著高于男性（P＝0.001）；血清骨钙素与血清磷水平存在相关性，相关系数为0.243（P＝0.001）；与骨质疏松风险指数存在负相关，相关系数为－0.197（P＝0.002）；与年龄（相关系数－0.157，P＝0.056），25-羟维生素D（－0.156， P＝0.194）、血清钙（相关系数0.055，P＝0.368）均无相关性。结论在中老年人群中，女性骨钙素水平明显高于男性，在应用该指标时应该考虑性别因素；骨钙素与骨质疏松风险指数T存在相关性，可以用于评估骨质疏松。
목적：연구중노년인군불동성별지간혈청골개소수평시부존재차이，이급골개소수평여골질소송지표、기타골대사지표시부존재상관성。방법선취2011년1～8월중노년건강체검자270명，배제악성종류급만성기출성질병，기중남성101례，년령50～89세，중위년령68세，녀성169례，년령50～89세，중위년령64세。사용골밀도의진행골밀도검측，검측지표위T치；분별진행혈청표본중골개소、25-간유생소D、개화린검측。불동성별지간골개소수평적비교채용 Mann-Whitney검험，장골개소수평여골질소송풍험지수、년령、개、린화25-간유생소 D적상관성진행 Spearman질상관분석，P＜0.05위차이유통계학의의。결과270례중노년건강체검자적T치、골개소、25-간유생소D、개화린수평범위분별위－3.5～－0.7（중위수평－1.6 ng／ml），3.59～264.90 ng／ml（중위수평12.84 ng／ml），4.0～34.0 ng／ml（중위수평10.5 ng／ml），1.79～2.69 mmol／L（중위수평2.36 ng／ml），0.43～2.89 mmol／L（중위수평1.12 ng／ml）；불동성별지간골개소존재차이，녀성수평현저고우남성（P＝0.001）；혈청골개소여혈청린수평존재상관성，상관계수위0.243（P＝0.001）；여골질소송풍험지수존재부상관，상관계수위－0.197（P＝0.002）；여년령（상관계수－0.157，P＝0.056），25-간유생소D（－0.156， P＝0.194）、혈청개（상관계수0.055，P＝0.368）균무상관성。결론재중노년인군중，녀성골개소수평명현고우남성，재응용해지표시응해고필성별인소；골개소여골질소송풍험지수T존재상관성，가이용우평고골질소송。
Objective To evaluate differences of serum bone gamma-carboxyglutamic-acid-containing protein (BGP)levels be-tween different gender in the middle-aged and elder population and the correlation between serum BGP and osteoporosis,as well as the correlation between BGP and other bone metabolic markers.Methods The study population consisted of 270 health care middle-aged and elder people,who were excluded malignancy and chronic diseases,during 2011 January to Au-gust.Of all the Recipients,101 cases were male,aged 50 to 89 years,with a median age of 68 years old,female 169 cases, aged 50 to 89 years,with a median age of 64 years.Bone density were measured by absorptiometry and was evaluated by the T index values.Serum BGP,25-hydroxyvitamin D,calcium and phosphorus were measured by different assays systems.The different level of BGP between genders was also analyzed by Mann-Whitney test.Correlation between BGP and serum calci-um,phosphorus,25-hydroxyvitamin D,osteoporosis risk index were analyzed Spearman rank correlation analysis.Results T value,BGP,25-hydroxy vitamin D,calcium and phosphorus levels range of 270 cases were-3.5~-0.7 (median-1.6 ng/ml),3.59~264.90 ng/ml (median 12.84 ng/ml),4.0~34.0 ng/ml (media 10.5 ng/ml),1.79~2.69 mmol/L (median 2.36 ng/ml),0.43~2.89 mmol/L (median 1.12 ng/ml),respectively.BGP levels in the female groups were significantly higher than the male groups.Serum concentration of BGP was positively correlated with serum phosphorus,but the serum BGP with calcium,25-hydroxy vitamin D,age and osteoporosis risk indices were not correlated.Conclusion In the elder groups,female BGP levels were significantly higher than male,the gender factor should be considered in the clinical applica-tion of BGP.Since BGP and osteoporosis risk index T had positive correlation,those two tests can be combined to evaluate osteoporosis.