CAJ | 학술논문

目的：研究呼吸纯氧对健康人听感觉门控P50的影响。方法右利手、健康男性大学生志愿者28名，根据随机数字表分为对照组(n=12)和实验组(n=16)。佩戴面罩，对照组呼吸空气，实验组呼吸医用纯氧60 min。应用条件-测试刺激，记录吸氧前(pre0)、吸氧20 min (Oxy20)、吸氧50 min (Oxy50)、吸氧后30 min (post30)的脑电图，计算听觉P50潜伏期和P50感觉门控电位(S1与S2振幅之差)。结果 S1刺激在4个时间点各组P50潜伏期相对稳定(P>0.7)；吸氧50 min时，实验组比对照组P50潜伏期缩短(P<0.05)。S2刺激在4个时间点各组P50潜伏期相对稳定(P>0.30)，两组间比较无显著性差异(P>0.05)。对照组P50门控电位比较稳定(P=0.70)，而实验组随吸氧时间逐渐延长，电位越来越高，停止吸氧后，电位迅速回落，Oxy20和post30(P=0.04)、Oxy50和post30(P=0.02)相比均有显著性差异。组间比较，4个时间点均无显著性差异(P>0.05)。结论健康人吸60 min纯氧，可能缩短对刺激的反应时间，有增强听觉门控电位的趋势。
목적：연구호흡순양대건강인은감각문공P50적영향。방법우리수、건강남성대학생지원자28명，근거수궤수자표분위대조조(n=12)화실험조(n=16)。패대면조，대조조호흡공기，실험조호흡의용순양60 min。응용조건-측시자격，기록흡양전(pre0)、흡양20 min (Oxy20)、흡양50 min (Oxy50)、흡양후30 min (post30)적뇌전도，계산은각P50잠복기화P50감각문공전위(S1여S2진폭지차)。결과 S1자격재4개시간점각조P50잠복기상대은정(P>0.7)；흡양50 min시，실험조비대조조P50잠복기축단(P<0.05)。S2자격재4개시간점각조P50잠복기상대은정(P>0.30)，량조간비교무현저성차이(P>0.05)。대조조P50문공전위비교은정(P=0.70)，이실험조수흡양시간축점연장，전위월래월고，정지흡양후，전위신속회락，Oxy20화post30(P=0.04)、Oxy50화post30(P=0.02)상비균유현저성차이。조간비교，4개시간점균무현저성차이(P>0.05)。결론건강인흡60 min순양，가능축단대자격적반응시간，유증강은각문공전위적추세。
Objective To explore the effect of oxygen inhalation on auditory sensory gating P50 in healthy human brain. Methods 28 healthy male academician right-handed were included. They were divided into control group (n=12) and experiment group (n=16) according to the random numerical table, and blinded about groups. The subjects inhaled pure oxygen in the experiment group, and air in the control group through a mask for 60 min. The electroencephalograph was recorded while an auditory paired-click sensory gating test was conducted during 4 study periods:before inhalation (pre0), inhale for 20 min (Oxy20) and 50 min (Oxy50), and 30 min after inhalation (post30). The la-tency and amplitude (S1-S2) of auditory sensory gating P50 were calculated. Results The latencies of P50 from S1 were stable in each group (P>0.7), and the latency of Oxy50 was shorter in the experiment group than in the control group (P<0.05). The latencies from S2 were stable in each group (P>0.30), and there was no significant difference between groups in all the time points (P>0.05). The amplitudes of (S1-S2) of P50 were stable in the control group (P=0.70), and was higher on Oxy20 (P=0.04) and Oxy50 (P=0.02) than post30 in the experi-ment group. There was no difference between the groups in all the time points (P>0.05). Conclusion Oxygen inhalation may be helpful to shorten the active time to stimulate, and trend to enhancing the amplitude of P50.