CAJ | 학술논문

目的：探讨吲哚布芬酯类化合物的设计与合成。方法依据药物化学中的拼合原理和前药原理，以吲哚布芬为起始原料，设计并合成了3个吲哚布芬酯类化合物。结果其结构均经IR、MS、1 H NMR、13 C NMR确证。结论所合成目标化合物的体外抗血小板聚集活性实验正在进行中。
목적：탐토신타포분지류화합물적설계여합성。방법의거약물화학중적병합원리화전약원리，이신타포분위기시원료，설계병합성료3개신타포분지류화합물。결과기결구균경IR、MS、1 H NMR、13 C NMR학증。결론소합성목표화합물적체외항혈소판취집활성실험정재진행중。
Indobufen was used as starting material, and three Indobufen esters were designed and synthesized based on association prin-ciple and prodrug principle of medicinal chemistry.The structures of the target compounds were characterized by IR, MS, 1 H NMR and 13 C NMR.The anti-platelet aggregation activity of the target compounds are being tested in vitro.