CAJ | 학술논문

目的：探讨非小细胞肺癌患者在术后辅助化疗中应用脾多肽注射液的临床效果。方法127例术后需行辅助化疗的非小细胞肺癌患者随机为观察组（65例）和对照组（62例）。观察组在辅助化疗同时加用脾多肽注射液，对照组仅给予辅助化疗。观察2组患者治疗后的全身状况、毒副反应并进行外周血T细胞亚群分析。结果辅助化疗后，观察组患者的平均KPS评分明显高于对照组（87.2±6.4 vs.74.2±5.9，P＜0.05），且观察组T细胞亚群分析各项免疫指标也显著优于对照组（P＜0.05）；观察组化疗相关血液毒性发生率低于对照组（P＜0.05）。结论在非小细胞肺癌患者术后辅助化疗过程中，应用脾多肽注射液能有效改善患者的全身状况和免疫功能。
목적：탐토비소세포폐암환자재술후보조화료중응용비다태주사액적림상효과。방법127례술후수행보조화료적비소세포폐암환자수궤위관찰조（65례）화대조조（62례）。관찰조재보조화료동시가용비다태주사액，대조조부급여보조화료。관찰2조환자치료후적전신상황、독부반응병진행외주혈T세포아군분석。결과보조화료후，관찰조환자적평균KPS평분명현고우대조조（87.2±6.4 vs.74.2±5.9，P＜0.05），차관찰조T세포아군분석각항면역지표야현저우우대조조（P＜0.05）；관찰조화료상관혈액독성발생솔저우대조조（P＜0.05）。결론재비소세포폐암환자술후보조화료과정중，응용비다태주사액능유효개선환자적전신상황화면역공능。
Objective To investigate the clinical effects of Lienal Polypeptide Injection combined with post-oper-ative chemotherapy in patients with non-small cell lung cancer after surgical therapy. Methods One hundred and twen-ty-seven post-operative patients with non-small cell lung cancer were randomly divided into investigative group (n=65) and control group (n=62). Patients in the investigative group were administrated with Lienal Polypeptide Injections when undergoing post-operative adjective chemotherapy, while patients in the control group were given only adjective chemotherapy. Results After chemotherapy, the average KPS value in patients of the investigative group was higher than that in the control group (87.2±6.4 vs.74.2±5.9, P<0.05). At the same time, the rate of chemotherapy related hematologic toxicity in the investigative group was significantly lower than that in the control group (P< 0.05). Conclusion During post-operative chemotherapy, the addition of Lienal Polypeptide Injection will improve the general condition and the im-mune ability of patients with non-small cell lung cancer.