中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2015年
1期
108-110
,共3页
尿白蛋白排泄率/肌酐%2型糖尿病%肾素-血管紧张素系统%血管紧张素Ⅱ%醛固酮
尿白蛋白排洩率/肌酐%2型糖尿病%腎素-血管緊張素繫統%血管緊張素Ⅱ%醛固酮
뇨백단백배설솔/기항%2형당뇨병%신소-혈관긴장소계통%혈관긴장소Ⅱ%철고동
A/C%Type 2 diabetes melitus%Renin-angiotensin system%AngiotensinⅡ%Aldosterone
目的：研究2型糖尿病患者尿白蛋白/肌酐（A/C）与肾素-血管紧张素系统（RAS）活性的相关性。方法选择160例2型糖尿病患者行A/C检测，将其分为A/C正常组96例（A/C≤30 mg/g）及A/C异常组64例（A/C＞30 mg/g），选择健康志愿者作为对照组（60例），检测三组研究对象静脉血RAS指标并比较各组的差异性，采用Logistic回归分析患者A/C与RAS各指标的相关性。结果 A/C异常组及A/C正常组患者静脉血肾素（PRA）、血管紧张素Ⅱ（AngⅡ）及醛固酮水平均高于对照组，A/C异常组患者静脉血PRA、AngⅡ及醛固酮水平均高于A/C正常组，差异均具有显著性（P＜0.05）。Logistic回归分析显示，A/C与静脉血PRA无明显相关性（P＞0.05），A/C与AngⅡ、醛固酮水平呈正相关（r＝0.495，0.316；P＝0.000，0.002）。结论2型糖尿病患者A/C与RAS活性具有相关性，RAS激活可能与2型糖尿病患者肾及血管损伤有关，A/C检测能够反映患者体内RAS激活程度，为2型糖尿病患者微循环损伤的早期发现提供新的指标。
目的：研究2型糖尿病患者尿白蛋白/肌酐（A/C）與腎素-血管緊張素繫統（RAS）活性的相關性。方法選擇160例2型糖尿病患者行A/C檢測，將其分為A/C正常組96例（A/C≤30 mg/g）及A/C異常組64例（A/C＞30 mg/g），選擇健康誌願者作為對照組（60例），檢測三組研究對象靜脈血RAS指標併比較各組的差異性，採用Logistic迴歸分析患者A/C與RAS各指標的相關性。結果 A/C異常組及A/C正常組患者靜脈血腎素（PRA）、血管緊張素Ⅱ（AngⅡ）及醛固酮水平均高于對照組，A/C異常組患者靜脈血PRA、AngⅡ及醛固酮水平均高于A/C正常組，差異均具有顯著性（P＜0.05）。Logistic迴歸分析顯示，A/C與靜脈血PRA無明顯相關性（P＞0.05），A/C與AngⅡ、醛固酮水平呈正相關（r＝0.495，0.316；P＝0.000，0.002）。結論2型糖尿病患者A/C與RAS活性具有相關性，RAS激活可能與2型糖尿病患者腎及血管損傷有關，A/C檢測能夠反映患者體內RAS激活程度，為2型糖尿病患者微循環損傷的早期髮現提供新的指標。
목적：연구2형당뇨병환자뇨백단백/기항（A/C）여신소-혈관긴장소계통（RAS）활성적상관성。방법선택160례2형당뇨병환자행A/C검측，장기분위A/C정상조96례（A/C≤30 mg/g）급A/C이상조64례（A/C＞30 mg/g），선택건강지원자작위대조조（60례），검측삼조연구대상정맥혈RAS지표병비교각조적차이성，채용Logistic회귀분석환자A/C여RAS각지표적상관성。결과 A/C이상조급A/C정상조환자정맥혈신소（PRA）、혈관긴장소Ⅱ（AngⅡ）급철고동수평균고우대조조，A/C이상조환자정맥혈PRA、AngⅡ급철고동수평균고우A/C정상조，차이균구유현저성（P＜0.05）。Logistic회귀분석현시，A/C여정맥혈PRA무명현상관성（P＞0.05），A/C여AngⅡ、철고동수평정정상관（r＝0.495，0.316；P＝0.000，0.002）。결론2형당뇨병환자A/C여RAS활성구유상관성，RAS격활가능여2형당뇨병환자신급혈관손상유관，A/C검측능구반영환자체내RAS격활정도，위2형당뇨병환자미순배손상적조기발현제공신적지표。
Objective To study relativity between ratio of urinary protein to creatinine (A/C) and activity of renin-angiotensinsystem on patients with type 2 diabetes melitus. Method 160 cases of patients with type 2 diabetes melitus were selected and divided into A/C normal group (96 cases) and A/C abnormal group (64 cases) according to weather with normal A/C, and 60 health volunteers were selected as control group, and all patients and voluntary were detected and contrasted with index of RAS between the three groups, then relativity between A/C and index of RAS were analysied with Logistic regression analysis. Result A/C abnormal group and A/C normal group patients with venous renin (PRA), angiotensinⅡ(AngⅡ) and aldosterone levels were higher than control group, A/C abnormal group vein blood of patients with PRA, AngⅡand aldosterone levels were higher than A/C normal group, the difference was signiifcant (P < 0.05). Logistic regression analysis showed no signiifcant correlation between the A/C and venous PRA (P>0.05), A/C and AngⅡ, aldosterone levels were positively correlated (r = 0.495, 0.316;P = 0.000, 0.002). Conclusion There is a relativity between A/C and activity of RAS on patients with type 2 diabetes melitus, activation of RAS maybe is a reason of renal and damage, and detecting A/C can relfect degree of RAS activation.
