催化学报
催化學報
최화학보
CHINESE JOURNAL OF CATALYSIS
2015年
3期
367-371
,共5页
赵文善%曲程科%杨莉莉%崔元臣
趙文善%麯程科%楊莉莉%崔元臣
조문선%곡정과%양리리%최원신
壳聚糖%辛可宁%负载型催化剂%直接不对称Aldol反应
殼聚糖%辛可寧%負載型催化劑%直接不對稱Aldol反應
각취당%신가저%부재형최화제%직접불대칭Aldol반응
Chitosan%Cinchonine%Supported catalyst%Direct asymmetric aldol reaction
以丁二酸酐为连接臂,经两步反应制备了壳聚糖负载辛可宁有机催化剂(CTS-SA-CN),并研究了CTS-SA-CN在水体系中对酮与多种芳香醛的直接不对称aldol反应的催化性能。结果表明,在CTS-SA-CN催化下,酮与多种芳香醛发生直接不对称aldol反应,可得到99%的产率和96%的ee值。另外, CTS-SA-CN可通过简单过滤实现回收,重复使用5次活性并没有明显下降。
以丁二痠酐為連接臂,經兩步反應製備瞭殼聚糖負載辛可寧有機催化劑(CTS-SA-CN),併研究瞭CTS-SA-CN在水體繫中對酮與多種芳香醛的直接不對稱aldol反應的催化性能。結果錶明,在CTS-SA-CN催化下,酮與多種芳香醛髮生直接不對稱aldol反應,可得到99%的產率和96%的ee值。另外, CTS-SA-CN可通過簡單過濾實現迴收,重複使用5次活性併沒有明顯下降。
이정이산항위련접비,경량보반응제비료각취당부재신가저유궤최화제(CTS-SA-CN),병연구료CTS-SA-CN재수체계중대동여다충방향철적직접불대칭aldol반응적최화성능。결과표명,재CTS-SA-CN최화하,동여다충방향철발생직접불대칭aldol반응,가득도99%적산솔화96%적ee치。령외, CTS-SA-CN가통과간단과려실현회수,중복사용5차활성병몰유명현하강。
Chitosan‐supported succinic anhydride‐cinchonine (CTS‐SA‐CN) was synthesized via a two‐step route with succinic anhydride as the linker. The catalyst was used to promote the direct asymmetric aldol reaction between cyclohexanone and a variety of aromatic aldehydes in aqueous medium. Aldol adducts were obtained in excellent yields (up to 99%) and good enantioselectivities (up to 96%ee). The CTS‐SA‐CN catalyst was successfully recycled simply by filtration after use, and was reused 5 times without any significant loss of activity.