CAJ | 학술논문

目的：系统评价中药联合TP方案（紫杉醇＋顺铂或紫杉醇＋卡铂）治疗晚期卵巢癌的疗效及不良反应。方法检索CNKI、VIP、CBM和万方数据库，时限不限，检索策略为中药联合 TP方案治疗晚期卵巢癌的随机对照试验（ RCTs），运用RevMan 5．1软件进行 Meta分析。结果纳入的10篇RCTs显示，中药可增强TP方案治疗晚期卵巢癌的有效率〔OR＝0．69，95％CI＝（0．51，0．94），P＝0．02〕，改善患者的生存质量〔OR＝0．32，95％CI＝（0．14，0．70），P＝0．005〕，以及降低化疗药所引起的胃肠道反应〔OR＝2．47，95％CI＝（1．24，4．90），P＝0．01〕。结论中药可增强铂类化疗药常规治疗的有效率，减轻毒副作用。
목적：계통평개중약연합TP방안（자삼순＋순박혹자삼순＋잡박）치료만기란소암적료효급불량반응。방법검색CNKI、VIP、CBM화만방수거고，시한불한，검색책략위중약연합 TP방안치료만기란소암적수궤대조시험（ RCTs），운용RevMan 5．1연건진행 Meta분석。결과납입적10편RCTs현시，중약가증강TP방안치료만기란소암적유효솔〔OR＝0．69，95％CI＝（0．51，0．94），P＝0．02〕，개선환자적생존질량〔OR＝0．32，95％CI＝（0．14，0．70），P＝0．005〕，이급강저화료약소인기적위장도반응〔OR＝2．47，95％CI＝（1．24，4．90），P＝0．01〕。결론중약가증강박류화료약상규치료적유효솔，감경독부작용。
ABSTRACT:OBJECTIVE To evaluate efficacy and side effects of traditional Chinese medicine combined with TP regimen on advanced ovarian cancer patients .METHODS Data of randomized controlled trials ( RCTs ) of tradi-tional Chinese medicine combined with TP regimen were retrieved from CNKI , VIP, CBM and WANFANG data-base.Statistics analysis was performed by Revman 5.1 software.RESULTS 10 RCTs were included in the study.Meta-analysis showed that the efficacy was improved〔OR=0.69,95%CI =(0.51,0.94),P=0.02〕,the quality of life was lengthened〔OR=0.32 ,95%CI=( 0.14 ,0.70 ) , P=0.005〕, and the gastrointestinal reactions were decreased〔OR=2.47,95%CI=(1.24,4.90),P=0.01〕in TP regimen combined with traditional Chinese medicine on advanced ovarian cancer patients .CONCLUSION Traditional Chinese medicine has advantages of en-hancing efficacy and reducing toxicity in platinum therapy on advanced ovarian cancer patients .