CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病（COPD）急性加重期机械通气患者雾化吸入肝素的治疗效果以及对患者凝血功能的影响。方法选取我院2011年3月～2013年3月收治的COPD急性加重期患者86例，随机分为对照组和研究组各43例，对照组患者予以常规支持治疗，研究组患者单次雾化吸入肝素，比较两组患者的治疗效果和凝血功能变化。结果研究组治疗有效率为95.35%，对照组治疗有效率为76.74%，研究组优于对照组，差异有统计学意义(P＜0.05)；两组患者FBG值均下降，PT、APTT、PLT值均上升，但研究组各项凝血功能指标改善程度显著优于对照组，差异均有统计学意义（P＜0.05）。结论 COPD急性加重期患者雾化吸入肝素疗效理想、安全可靠，有助于改善COPD加重期患者凝血功能，值得在临床上推广应用。
목적：탐토만성조새성폐질병（COPD）급성가중기궤계통기환자무화흡입간소적치료효과이급대환자응혈공능적영향。방법선취아원2011년3월～2013년3월수치적COPD급성가중기환자86례，수궤분위대조조화연구조각43례，대조조환자여이상규지지치료，연구조환자단차무화흡입간소，비교량조환자적치료효과화응혈공능변화。결과연구조치료유효솔위95.35%，대조조치료유효솔위76.74%，연구조우우대조조，차이유통계학의의(P＜0.05)；량조환자FBG치균하강，PT、APTT、PLT치균상승，단연구조각항응혈공능지표개선정도현저우우대조조，차이균유통계학의의（P＜0.05）。결론 COPD급성가중기환자무화흡입간소료효이상、안전가고，유조우개선COPD가중기환자응혈공능，치득재림상상추엄응용。
Objective To investigate the influencing effect of AECOPD patients on mechanical ventilation treated with ultrasonic atomizing inhalation of heparin. Methods A total of 86 cases of patients with AECOPD in our hospital from Mar 2011 to Mar 2013 were selected as research subjects. All patients were equally divided into study group and control group, each group of 43 patients. Control group was given routine treatment, while study group was given ultrasonic atom-izing inhalation of heparin. Results The effective rate of study group was 95.33%, and that of control group was 76.74%. The difference between the two groups was statistically significant (P<0.05); Compared to control group, study group were better in PT, APTT and PLT. FBG declined in two groups. But the degree of improvement in coagulation parameters of the study group was significantly better than the control group, the differences between the two groups were statistical-ly significant(P<0.05). Conclusions Ultrasonic atomizing inhalation of heparin in treating patients with AECOPD was safe and reliable, and had remarkable improvement in coagulation function of patients with AECOPD. It was worth using in clinical.