CAJ | 학술논문

渗出性年龄相关性黄斑变性(AMD)是导致老年人中心视力丧失的重要原因之一,其病理机制为脉络膜新生血管(CNV)的形成.近年来研究者发现,促血管生成因子与抗血管生成因子的平衡在CNV的形成中起重要作用,其中血管内皮生长因子(VEGF)与色素上皮衍生因子(PEDF)分别为促血管生成因子与抗血管生成因子的代表性因子.针对这些细胞因子的靶向治疗为渗出性AMD的药物治疗提供了新的方向,目前广泛应用于临床,抗VEGF药物在控制CNV并提高患者视力方面具有重要意义.本文就与渗出性AMD发病相关的多种细胞因子的作用机制及渗出性AMD的靶向治疗研究进展进行综述.
삼출성년령상관성황반변성(AMD)시도치노년인중심시력상실적중요원인지일,기병리궤제위맥락막신생혈관(CNV)적형성.근년래연구자발현,촉혈관생성인자여항혈관생성인자적평형재CNV적형성중기중요작용,기중혈관내피생장인자(VEGF)여색소상피연생인자(PEDF)분별위촉혈관생성인자여항혈관생성인자적대표성인자.침대저사세포인자적파향치료위삼출성AMD적약물치료제공료신적방향,목전엄범응용우림상,항VEGF약물재공제CNV병제고환자시력방면구유중요의의.본문취여삼출성AMD발병상관적다충세포인자적작용궤제급삼출성AMD적파향치료연구진전진행종술.
Exudative age-related macular degeneration (AMD) is the leading cause of central vision loss in elderly population,and its primary pathological mechanism is the formation of choroidal neovascularization (CNV).Recently,it is found that the balance of angiogenesis and antiangiogenic factors plays an important role in the formation of CNV,and the main factors are vascular endothelial growth factor (VEGF) and pigment epitheliumderived factor (PEDF).The targeting therapy for these cytokines provides a new approach to the treatment of exudative AMD.Anti-VEGF therapy is of great effect on controlling CNV and improving visual acuity in exudative AMD patients.The purpose of this review was to summarize current advance in the study of cytokines associated with the pathogenesis of exudative AMD and its targeting therapy.