中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
1期
86-88
,共3页
利拉鲁肽%胰升糖素样肽1%心血管系统%LEAD研究%糖尿病,2型
利拉魯肽%胰升糖素樣肽1%心血管繫統%LEAD研究%糖尿病,2型
리랍로태%이승당소양태1%심혈관계통%LEAD연구%당뇨병,2형
Liraglutide%Glucagon like peptide-1%Cardiovascular system%LEAD study%Diabetes mellitus,type 2
[提要]2型糖尿病常伴随超重或肥胖、高血压、高血脂等代谢异常状态,并与心血管风险的增加密不可分.目前大多数降糖药以降糖为主要机制,难以兼顾多种代谢异常状态并降低心血管风险.本文对利拉鲁肽在降低血糖的同时,对体重、血压、血脂的有益影响,以及对心血管系统可能的保护作用的临床研究进展作一综述.
[提要]2型糖尿病常伴隨超重或肥胖、高血壓、高血脂等代謝異常狀態,併與心血管風險的增加密不可分.目前大多數降糖藥以降糖為主要機製,難以兼顧多種代謝異常狀態併降低心血管風險.本文對利拉魯肽在降低血糖的同時,對體重、血壓、血脂的有益影響,以及對心血管繫統可能的保護作用的臨床研究進展作一綜述.
[제요]2형당뇨병상반수초중혹비반、고혈압、고혈지등대사이상상태,병여심혈관풍험적증가밀불가분.목전대다수강당약이강당위주요궤제,난이겸고다충대사이상상태병강저심혈관풍험.본문대리랍로태재강저혈당적동시,대체중、혈압、혈지적유익영향,이급대심혈관계통가능적보호작용적림상연구진전작일종술.
[Summary] Type 2 diabetes is usually associated with overweight or obesity,hypertension,hyperlipidaemia and increased cardiovascular risk.Most of the anti-diabetic drugs mainly work on glucose-lowering,therefore would not bring benefits to the multiple metabolic abnormalities.In this article,the multiple effects of the anti-diabetic drug liraglutide on body weight,blood pressure,blood lipids,and cardiovascular system were summarised.
