中国血吸虫病防治杂志
中國血吸蟲病防治雜誌
중국혈흡충병방치잡지
CHINESE JOURNAL OF SCHISTOSOMIASIS CONTROL
2015年
1期
26-31
,共6页
郏自明%岳苗苗%郑艳华%张金明%唐利军
郟自明%嶽苗苗%鄭豔華%張金明%唐利軍
겹자명%악묘묘%정염화%장금명%당리군
防蚴灵防护剂%兔%皮肤给药%长期毒性
防蚴靈防護劑%兔%皮膚給藥%長期毒性
방유령방호제%토%피부급약%장기독성
Fangyouling%Rabbits%Transdermal administration%Long term toxicity
目的:观察防蚴灵防护剂对兔反复经皮给药1个月的毒性反应,评价其安全性。方法40只兔随机分为溶媒对照组和防蚴灵防护剂低、中、高剂量组,对照组给予葵花籽油,各剂量组分别按50、300、2000 mg/kg经皮肤给予防蚴灵防护剂,每天1次,连续4周。观察兔的一般状况、皮肤刺激性反应、体重、摄食量、血液、血液生化、脏器系数及组织病理学变化。结果低、中、高剂量的防蚴灵防护剂对兔一般情况无明显影响;对照组和防蚴灵防护剂低剂量组的所有兔皮肤未见明显改变,中剂量组有2只、高剂量组有4只兔的皮肤可见轻度刺激性;高剂量防蚴灵防护剂对兔体重和摄食量有一定的抑制作用;各剂量防蚴灵防护剂对兔血液、血液生化和脏器均无明显影响。结论防蚴灵防护剂50 mg/kg为无毒性反应剂量。
目的:觀察防蚴靈防護劑對兔反複經皮給藥1箇月的毒性反應,評價其安全性。方法40隻兔隨機分為溶媒對照組和防蚴靈防護劑低、中、高劑量組,對照組給予葵花籽油,各劑量組分彆按50、300、2000 mg/kg經皮膚給予防蚴靈防護劑,每天1次,連續4週。觀察兔的一般狀況、皮膚刺激性反應、體重、攝食量、血液、血液生化、髒器繫數及組織病理學變化。結果低、中、高劑量的防蚴靈防護劑對兔一般情況無明顯影響;對照組和防蚴靈防護劑低劑量組的所有兔皮膚未見明顯改變,中劑量組有2隻、高劑量組有4隻兔的皮膚可見輕度刺激性;高劑量防蚴靈防護劑對兔體重和攝食量有一定的抑製作用;各劑量防蚴靈防護劑對兔血液、血液生化和髒器均無明顯影響。結論防蚴靈防護劑50 mg/kg為無毒性反應劑量。
목적:관찰방유령방호제대토반복경피급약1개월적독성반응,평개기안전성。방법40지토수궤분위용매대조조화방유령방호제저、중、고제량조,대조조급여규화자유,각제량조분별안50、300、2000 mg/kg경피부급여방유령방호제,매천1차,련속4주。관찰토적일반상황、피부자격성반응、체중、섭식량、혈액、혈액생화、장기계수급조직병이학변화。결과저、중、고제량적방유령방호제대토일반정황무명현영향;대조조화방유령방호제저제량조적소유토피부미견명현개변,중제량조유2지、고제량조유4지토적피부가견경도자격성;고제량방유령방호제대토체중화섭식량유일정적억제작용;각제량방유령방호제대토혈액、혈액생화화장기균무명현영향。결론방유령방호제50 mg/kg위무독성반응제량。
Objective To observe the toxicity of fangyouling after one month’s transdermal administration in rabbits and evaluate its security. Methods Forty rabbits were randomly divided into 4 groups including a control group and low,middle and high dose groups of fangyouling. The rabbits in the control group were administered with sunflower oil,and the other rabbits were administrated dermally with fangyouling of 50,300 and 2 000 mg/kg respectively once a day for 4 weeks. The general con?dition,the skin irritation reaction,body weight,food consumption,hematology,blood biochemistry,organ coefficients and his?topathological changes of all the rabbits were observed. Results There was no obvious effect on the general condition in all the rabbits. However,the mild skin irritation was observed in 2 rabbits of the middle dose group and 4 rabbits of the high?dose group. The decreases of body weight and food consumption were noted in the high dose group. No changes were detected of hema?tology,blood biochemistry or viscera pathological at all dose levels. Conclusion The dose of non?toxic response of fangyouling is 50 mg/kg at this study condition.