中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2015年
1期
20-22
,共3页
葡糖耐量试验%二甲双胍%凝血功能
葡糖耐量試驗%二甲雙胍%凝血功能
포당내량시험%이갑쌍고%응혈공능
Glucose tolerance test%Metformin%Blood coagulation function
目的 探讨糖耐量异常患者凝血功能变化及二甲双胍的干预效应.方法 将100例糖耐量异常患者按照随机数字表法分为试验1组和试验2组,每组50例,另选择健康志愿者50例作为对照组.试验2组给予二甲双胍治疗,试验1组给予安慰剂治疗.治疗前后各组行口服葡萄糖耐量试验(OGTT),检测糖负荷后2h血糖(2 h PBG),并检测糖化血红蛋白以及凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib).结果 治疗前试验1组和试验2组2 h PBG、糖化血红蛋白、Fib均明显高于对照组,Am、PT明显低于对照组,差异有统计学意义(P＜0.05).治疗后试验2组2 h PBG、糖化血红蛋白、Fib明显低于试验1组[(6.6±2.5) mmol/L比(7.9±3.6)mmol/L、(5.2±1.3)％比(5.8±1.4)％、(3.0±1.0) g/L比(3.6±1.2) g/L],APTT、PT明显高于试验1组[(34.3±6.8)s比(31.6±6.5)s、(12.6±0.7)s比(12.3±0.7)s],差异有统计学意义(P＜0.05),且与对照组比较差异无统计学意义(P＞0.05).三组TT比较差异均无统计学意义(P＞0.05).Pearson直线相关分析结果显示,APTT、PT与2hPBG和糖化血红蛋白呈负相关(P＜0.01),Fib与2h PBG和糖化血红蛋白呈正相关(P＜0.01),TT与2hPBG和糖化血红蛋白无相关性(P＞0.05).结论 糖耐量异常患者已出现凝血功能异常,适当的干预治疗可降低心血管疾病的危险因素.
目的 探討糖耐量異常患者凝血功能變化及二甲雙胍的榦預效應.方法 將100例糖耐量異常患者按照隨機數字錶法分為試驗1組和試驗2組,每組50例,另選擇健康誌願者50例作為對照組.試驗2組給予二甲雙胍治療,試驗1組給予安慰劑治療.治療前後各組行口服葡萄糖耐量試驗(OGTT),檢測糖負荷後2h血糖(2 h PBG),併檢測糖化血紅蛋白以及凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)、凝血酶時間(TT)、纖維蛋白原(Fib).結果 治療前試驗1組和試驗2組2 h PBG、糖化血紅蛋白、Fib均明顯高于對照組,Am、PT明顯低于對照組,差異有統計學意義(P＜0.05).治療後試驗2組2 h PBG、糖化血紅蛋白、Fib明顯低于試驗1組[(6.6±2.5) mmol/L比(7.9±3.6)mmol/L、(5.2±1.3)％比(5.8±1.4)％、(3.0±1.0) g/L比(3.6±1.2) g/L],APTT、PT明顯高于試驗1組[(34.3±6.8)s比(31.6±6.5)s、(12.6±0.7)s比(12.3±0.7)s],差異有統計學意義(P＜0.05),且與對照組比較差異無統計學意義(P＞0.05).三組TT比較差異均無統計學意義(P＞0.05).Pearson直線相關分析結果顯示,APTT、PT與2hPBG和糖化血紅蛋白呈負相關(P＜0.01),Fib與2h PBG和糖化血紅蛋白呈正相關(P＜0.01),TT與2hPBG和糖化血紅蛋白無相關性(P＞0.05).結論 糖耐量異常患者已齣現凝血功能異常,適噹的榦預治療可降低心血管疾病的危險因素.
목적 탐토당내량이상환자응혈공능변화급이갑쌍고적간예효응.방법 장100례당내량이상환자안조수궤수자표법분위시험1조화시험2조,매조50례,령선택건강지원자50례작위대조조.시험2조급여이갑쌍고치료,시험1조급여안위제치료.치료전후각조행구복포도당내량시험(OGTT),검측당부하후2h혈당(2 h PBG),병검측당화혈홍단백이급응혈매원시간(PT)、활화부분응혈활매시간(APTT)、응혈매시간(TT)、섬유단백원(Fib).결과 치료전시험1조화시험2조2 h PBG、당화혈홍단백、Fib균명현고우대조조,Am、PT명현저우대조조,차이유통계학의의(P＜0.05).치료후시험2조2 h PBG、당화혈홍단백、Fib명현저우시험1조[(6.6±2.5) mmol/L비(7.9±3.6)mmol/L、(5.2±1.3)％비(5.8±1.4)％、(3.0±1.0) g/L비(3.6±1.2) g/L],APTT、PT명현고우시험1조[(34.3±6.8)s비(31.6±6.5)s、(12.6±0.7)s비(12.3±0.7)s],차이유통계학의의(P＜0.05),차여대조조비교차이무통계학의의(P＞0.05).삼조TT비교차이균무통계학의의(P＞0.05).Pearson직선상관분석결과현시,APTT、PT여2hPBG화당화혈홍단백정부상관(P＜0.01),Fib여2h PBG화당화혈홍단백정정상관(P＜0.01),TT여2hPBG화당화혈홍단백무상관성(P＞0.05).결론 당내량이상환자이출현응혈공능이상,괄당적간예치료가강저심혈관질병적위험인소.
Objective To investigate the blood coagulation function changes and intervention effects of metformin in patients with impaired glucose tolerance.Methods One hundred patients with impaired glucose tolerance and 50 healthy volunteers (control group) were recruited.The patients with impaired glucose tolerance were divided into test group 1 and test group 2 by random digits table method.The patients in test group 2 were given metformin and the patients in test group 1 were given the same dosage of placebo.The oral glucose tolerance test (OGTT),glycosylated hemoglobin (HbA1c),prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT) and fibrinogen (Fib) level were determined before and after treatment.Results Compared with those in control group,the patients in test group 1 and test group 2 had higher level of 2 h postprandial blood glucose (2 h PBG),HbA1c and Fib,and lower level of APTT,PT (P ＜ 0.05).The level of 2 h PBG,HbA1c and Fib in test group 2 were significantly lower than those in test group 1,(6.6 ± 2.5) mmol/L vs.(7.9 ± 3.6) mmol/L,(5.2 ± 1.3)％ vs.(5.8 ± 1.4)％,(3.0 ± 1.0) g/L vs.(3.6 ± 1.2) g/L,and the level of APTT and PT were significantly higher than those in test group 1,(34.3 ± 6.8) s vs.(31.6 ± 6.5) s,(12.6 ± 0.7) s vs.(12.3 ± 0.7) s,P ＜ 0.05.Compared with those in control group,there were no significant differences (P ＞ 0.05).Pearson line correlation analysis revealed that APTT and PT had negative correlation with 2 h PBG and HbA1c (P ＜ 0.01),and Fib had positive correlation with 2 h PBG and HbA1c (P ＜ 0.01).TT had no correlation with 2 h PBG and HbA1c (P ＞ 0.05).Conclusion Blood coagulation function of patients with impaired glucose tolerance may have some alteration,and appropriate therapeutic intervention can reduce the risk factors for cardiovascular disease.
