国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2015年
1期
28-30
,共3页
皮炎,特应性%CD4阳性T淋巴细胞%免疫学
皮炎,特應性%CD4暘性T淋巴細胞%免疫學
피염,특응성%CD4양성T림파세포%면역학
Dermatitis,atopic%CD4-positive T-lymphocytes%Immunology
特应性皮炎是慢性复发性炎症性皮肤病,皮肤屏障功能破坏、金黄色葡萄球菌定植造成的持续抗原刺激、免疫细胞调节功能失衡是其发病的关键因素.免疫细胞调控网络结构复杂,其通过细胞因子合成分泌的相互调节、受体表达的相互调控、生物学效应的相互影响发挥重要作用.关于CD4+辅助性T细胞在特应性皮炎发病机制中的作用,近年来基础及临床研究均有进展.
特應性皮炎是慢性複髮性炎癥性皮膚病,皮膚屏障功能破壞、金黃色葡萄毬菌定植造成的持續抗原刺激、免疫細胞調節功能失衡是其髮病的關鍵因素.免疫細胞調控網絡結構複雜,其通過細胞因子閤成分泌的相互調節、受體錶達的相互調控、生物學效應的相互影響髮揮重要作用.關于CD4+輔助性T細胞在特應性皮炎髮病機製中的作用,近年來基礎及臨床研究均有進展.
특응성피염시만성복발성염증성피부병,피부병장공능파배、금황색포도구균정식조성적지속항원자격、면역세포조절공능실형시기발병적관건인소.면역세포조공망락결구복잡,기통과세포인자합성분비적상호조절、수체표체적상호조공、생물학효응적상호영향발휘중요작용.관우CD4+보조성T세포재특응성피염발병궤제중적작용,근년래기출급림상연구균유진전.
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease.Skin barrier impairment,constant antigenic stimulation caused by Staphylococcus aureus colonization,and immune cell dysfunction are the main pathogenesis of AD.The complicated regulatory network of immunocytes plays an important role in the pathogenesis of AD through the mutual regulation of cytokine synthesis and secretion as well as receptor expression,and mutual influence between biological effects.In recent years,some progress has been made in basic and clinical researches on the role of CD4 + T helper cells in the pathogenesis of AD.
