CAJ | 학술논문

银屑病是一种病因不明的慢性炎症性、免疫性疾病,其皮损中可发现明显增多的树突细胞和效应性T细胞浸润,提示树突细胞参与了银屑病的炎症反应.正常皮肤组织中,主要分布3类树突细胞:表皮朗格汉斯细胞、真皮髓系树突细胞和浆细胞样树突细胞.在银屑病皮损组织中,3类树突细胞与T细胞、角质形成细胞、中性粒细胞的相互作用可引发和加重皮肤中的炎症反应.此外,浆细胞样树突细胞在以Toll样受体依赖方式分泌的Ⅰ型干扰素还可能促进髓系树突细胞的活化及炎症介质的释放.
은설병시일충병인불명적만성염증성、면역성질병,기피손중가발현명현증다적수돌세포화효응성T세포침윤,제시수돌세포삼여료은설병적염증반응.정상피부조직중,주요분포3류수돌세포:표피랑격한사세포、진피수계수돌세포화장세포양수돌세포.재은설병피손조직중,3류수돌세포여T세포、각질형성세포、중성립세포적상호작용가인발화가중피부중적염증반응.차외,장세포양수돌세포재이Toll양수체의뢰방식분비적Ⅰ형간우소환가능촉진수계수돌세포적활화급염증개질적석방.
Psoriasis is a chronic inflammatory and immunologic disease of unknown etiology.It has been found that increased number of dendritic cells (DCs) and effector T-lymphocytes infiltrate skin lesions of psoriasis,indicating that DCs are involved in the inflammatory response in psoriasis.In normal skin,there are mainly three kinds of DCs:epidermal Langerhans cells,dermal myeloid DCs and plasmacytoid DCs.In skin lesions of psoriasis,the three kinds of DCs interact with T cells,keratinocytes and neutrophilic granulocytes,which can induce and aggravate inflammatory responses.In addition,type Ⅰ interferon secreted by plasmacytoid DCs in a Toll-like receptor-dependent manner can enhance the activation of myeloid DCs and release of inflammatory mediators.