CAJ | 학술논문

载脂蛋白B mRNA编辑酶催化多肽家族是一种通过脱氨酶作用编辑DNA和RNA序列的抗病毒活性蛋白分子.最初载脂蛋白B mRNA编辑酶催化多肽3家族因具有抑制HIV复制的作用而得到关注.随着研究的深入,发现载脂蛋白B mRNA编辑酶催化多肽家族在与人类疾病密切相关的其他病毒感染如人类嗜T细胞病毒、丙型肝炎病毒、乙型肝炎病毒、人乳头瘤病毒、单纯疱疹病毒中同样发挥重要作用.此外,载脂蛋白B mRNA编辑酶催化多肽的编辑作用不仅是病毒基因多样性和进化性的来源,也是肿瘤发生的重要原因.
재지단백B mRNA편집매최화다태가족시일충통과탈안매작용편집DNA화RNA서렬적항병독활성단백분자.최초재지단백B mRNA편집매최화다태3가족인구유억제HIV복제적작용이득도관주.수착연구적심입,발현재지단백B mRNA편집매최화다태가족재여인류질병밀절상관적기타병독감염여인류기T세포병독、병형간염병독、을형간염병독、인유두류병독、단순포진병독중동양발휘중요작용.차외,재지단백B mRNA편집매최화다태적편집작용불부시병독기인다양성화진화성적래원,야시종류발생적중요원인.
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family are a group of active antiviral proteins that can edit DNA and RNA sequences by deamidizing enzymes.The APOBEC-like 3 (APOBEC3) family was firstly noticed for its inhibitory effect against human immunodeficiency virus type 1 (HIV-1) infection.With the development of research,the APOBEC family have been found to play an important role in other viral infections closely related to human diseases,such as human T-cell lymphotropic virus (HTLV),hepatitis C virus (HCV),hepatitis B virus (HBV),human papilloma virus (HPV),herpes simplex virus (HSV),etc.In addition,the editing function of the APOBEC family contributes not only to viral genetic diversity and evolution,but also to tumorigenesis.