CAJ | 학술논문

经典Wnt信号通路是近几年来卵巢癌发生相关信号通路研究的热点,激活后可诱导卵巢癌干细胞增殖及自我更新、存活及转移,其主要成员靶基因突变及传导通路负性调控分子异常表达与卵巢癌发生发展密切相关.深入了解经典Wnt信号通路在卵巢癌中的调控机制,并以此为抗卵巢癌治疗靶点进行基础研究及临床前期实验,可为临床更好地治疗卵巢癌提供理论依据.
경전Wnt신호통로시근궤년래란소암발생상관신호통로연구적열점,격활후가유도란소암간세포증식급자아경신、존활급전이,기주요성원파기인돌변급전도통로부성조공분자이상표체여란소암발생발전밀절상관.심입료해경전Wnt신호통로재란소암중적조공궤제,병이차위항란소암치료파점진행기출연구급림상전기실험,가위림상경호지치료란소암제공이론의거.
The canonical Wnt signaling pathway has been the hot spot in the signaling pathway studies which are related to ovary carcinogenesis in recent years,whose activation may induce the multiplication and self-renewal,survival and metastasis of ovarian cancer stem cells.The target gene mutations of key members in the canonical Wnt pathway and abnormal expresses of negative regulation molecules are closely associated with the occurrence and development of ovarian cancer.Deeply investigating the regulative mechanisms of canonical Wnt signaling pathway in ovarian cancer,and taking this as the therapeutic target to conduct the basic research and preclinical experiment may provide theoretical basis for treating better ovarian cancer patients in clinical practice.