CAJ | 학술논문

目的探讨儿童过敏性紫癜的临床特点.方法收集住院过敏性紫癜患儿760例,分析发病年龄、性别、发病季节、临床表现、并发症、伴紫癜性肾炎的临床和病理特点.结果发病年龄以学龄前和学龄期儿童为主,冬、春季节为多.伴消化道症状265例,占34.87％;伴关节症状298例,占39.21％;伴肾脏损害223例,占29.34％.紫癜性肾炎以血尿和蛋白尿、肾炎综合征为主,病理类型主要为Ⅱ～Ⅲ级,共91例,占肾活检资料总数的91.91％.紫癜分布特点与并发症相关.结论过敏性紫癜有年龄、季节等特点.四肢紫癜者易出现消化道出血和关节症状,单纯下肢紫癜并发肾炎比四肢紫癜的要多.该病一般病情较轻,预后良好.
목적 탐토인동과민성자전적림상특점.방법 수집주원과민성자전환인760례,분석발병년령、성별、발병계절、림상표현、병발증、반자전성신염적림상화병리특점.결과 발병년령이학령전화학령기인동위주,동、춘계절위다.반소화도증상265례,점34.87％;반관절증상298례,점39.21％;반신장손해223례,점29.34％.자전성신염이혈뇨화단백뇨、신염종합정위주,병리류형주요위Ⅱ～Ⅲ급,공91례,점신활검자료총수적91.91％.자전분포특점여병발증상관.결론 과민성자전유년령、계절등특점.사지자전자역출현소화도출혈화관절증상,단순하지자전병발신염비사지자전적요다.해병일반병정교경,예후량호.
Objective To investigate the clinical characteristics of childhood anaphylactoid purpura.Methods Seven hundred and sixty children with anaphylactoid purpura were included in this retrospective study.The clinicopathological features of childhood anaphylactoid purpura were analyzed,including age at onset,gender,season at onset,clinical and pathological manifestations,and complications such as purpura nephritis.Results Childhood anaphylactoid purpura commonly affected preschool and school-age children,and usually occurred in winter or spring.Of these patients,265 (34.87％) had gastrointestinal symptoms,298 (39.21％) had joint involvement,and 223 (29.34％) had renal impairment.Purpura nephritis mainly manifested as haematuria,proteinuria and nephritic syndrome,and was diagnosed in 91.91％ (91) of the patients receiving renal biopsy.The pathological grade of purpura nephritis varied from Ⅱ to Ⅲ in these patients.The distribution pattern of purpura was associated with complications.Conclusions Anaphylactoid purpura has age and season predilection.Purpura in both lower and upper extremities is likely to be complicated by gastrointestinal haemorrhage and joint involvement,and lower extremity purpura is more frequently to be complicated by nephritis than purpura in both lower and upper extremities.In general,childhood anaphylactoid purpura is a mild condition with a good prognosis.