中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2015年
1期
37-40
,共4页
王朵勤%唐慧%沈燕芸%徐金华
王朵勤%唐慧%瀋燕蕓%徐金華
왕타근%당혜%침연예%서금화
荨麻疹%因子Ⅶa%因子Ⅻa
蕁痳疹%因子Ⅶa%因子Ⅻa
담마진%인자Ⅶa%인자Ⅻa
Urticaria%Factor Ⅶa%Factor Ⅻa
目的 探讨血浆D二聚体、活化凝血因子Ⅶ(FⅦa)及活化凝血因子Ⅻ(FⅫa)在慢性荨麻疹(CU)患者中的表达及其与CU发病的关系.方法 对50例CU患者及50例健康对照用干式免疫散射色谱法检测血浆D二聚体水平,用酶联免疫吸附法检测FⅦa及FⅫa的水平,并结合患者病情严重程度情况进行分析.对43例CU患者自体血浆皮肤试验(APST)及41例CU患者作自体血清皮肤试验(ASST)结果与其血浆D二聚体水平进行比较.结果 CU患者血浆中D二聚体及FⅦa的水平均明显高于健康对照组(P＜0.05),前者升高水平与病情严重程度呈正相关(P＜0.05);CU患者FⅫa水平与健康对照组比较,差异无统计学意义(P＞0.05).APST(+)患者的D二聚体水平明显高于APST(-)患者(P＜0.05),而ASST(+)患者D二聚体水平与ASST(-)患者比较,差异无统计学意义(P＞0.05).结论 凝血机制与CU相关,外源性凝血途径起着作用,针对凝血机制的研究对于CU的病情评估和临床治疗具有一定的意义.
目的 探討血漿D二聚體、活化凝血因子Ⅶ(FⅦa)及活化凝血因子Ⅻ(FⅫa)在慢性蕁痳疹(CU)患者中的錶達及其與CU髮病的關繫.方法 對50例CU患者及50例健康對照用榦式免疫散射色譜法檢測血漿D二聚體水平,用酶聯免疫吸附法檢測FⅦa及FⅫa的水平,併結閤患者病情嚴重程度情況進行分析.對43例CU患者自體血漿皮膚試驗(APST)及41例CU患者作自體血清皮膚試驗(ASST)結果與其血漿D二聚體水平進行比較.結果 CU患者血漿中D二聚體及FⅦa的水平均明顯高于健康對照組(P＜0.05),前者升高水平與病情嚴重程度呈正相關(P＜0.05);CU患者FⅫa水平與健康對照組比較,差異無統計學意義(P＞0.05).APST(+)患者的D二聚體水平明顯高于APST(-)患者(P＜0.05),而ASST(+)患者D二聚體水平與ASST(-)患者比較,差異無統計學意義(P＞0.05).結論 凝血機製與CU相關,外源性凝血途徑起著作用,針對凝血機製的研究對于CU的病情評估和臨床治療具有一定的意義.
목적 탐토혈장D이취체、활화응혈인자Ⅶ(FⅦa)급활화응혈인자Ⅻ(FⅫa)재만성담마진(CU)환자중적표체급기여CU발병적관계.방법 대50례CU환자급50례건강대조용간식면역산사색보법검측혈장D이취체수평,용매련면역흡부법검측FⅦa급FⅫa적수평,병결합환자병정엄중정도정황진행분석.대43례CU환자자체혈장피부시험(APST)급41례CU환자작자체혈청피부시험(ASST)결과여기혈장D이취체수평진행비교.결과 CU환자혈장중D이취체급FⅦa적수평균명현고우건강대조조(P＜0.05),전자승고수평여병정엄중정도정정상관(P＜0.05);CU환자FⅫa수평여건강대조조비교,차이무통계학의의(P＞0.05).APST(+)환자적D이취체수평명현고우APST(-)환자(P＜0.05),이ASST(+)환자D이취체수평여ASST(-)환자비교,차이무통계학의의(P＞0.05).결론 응혈궤제여CU상관,외원성응혈도경기착작용,침대응혈궤제적연구대우CU적병정평고화림상치료구유일정적의의.
Objective To measure the levels of plasma D-dimer,activated coagulation factor Ⅶ (FⅦa) and activated clotting factor Ⅻ (FⅫa) in patients with chronic urticaria (CU),and to investigate their relationship with the occurrence of CU.Methods Venous blood samples were collected from 50 patients with CU and 50 healthy human controls.Dry-column immune scattering chromatography was performed to detect the plasma level of D-dimer,and enzyme-linked immunosorbent assay (ELISA) to measure the levels of FⅦa and FⅫa.In addition,autologous plasma skin test (APST) was conducted in 43 patients with CU,and autologous serum skin test (ASST) in 41 patients with CU.A correlation analysis was carried out between the above three parameters and disease severity as well as between the results of APST and ASST and plasma level of D-dimer.Results The levels of plasma D-dimer and F Ⅶa were significantly higher in patients with CU than in healthy human controls (both P ＜ 0.05),while no significant difference was found in FⅫa level between the two groups (P ＞ 0.05).Moreover,the degree of increase in D-dimer plasma level was positively correlated with disease severity in the patients with CU.The plasma level of D-dimer was significantly higher in APST-positive patients than in APST-negative patients (P ＜ 0.05),but not significantly different between ASST-positive and-negative patients (P ＞ 0.05).Conclusions Coagulation mechanism,especially the extrinsic coagulation pathway,is related to the occurrence of CU.Studies on coagulation mechanism are beneficial to the evaluation of severity,and clinical treatment,of CU.
