CAJ | 학술논문

肝细胞核因子4α是一种细胞核激素受体超家族的转录因子,在消化系统分化发育及极性调控方面具有十分重要的作用,被认为是一种抑癌基因,在肝癌、结肠癌、胃癌等消化系统肿瘤的发生、侵袭及转移过程中发挥了十分重要的调控作用,并与上皮间质转化、细胞增殖调控及Wnt信号通路密切相关.肝细胞核因子4α在消化系统肿瘤中的表达及其作用机制是目前研究的热点.
간세포핵인자4α시일충세포핵격소수체초가족적전록인자,재소화계통분화발육급겁성조공방면구유십분중요적작용,피인위시일충억암기인,재간암、결장암、위암등소화계통종류적발생、침습급전이과정중발휘료십분중요적조공작용,병여상피간질전화、세포증식조공급Wnt신호통로밀절상관.간세포핵인자4α재소화계통종류중적표체급기작용궤제시목전연구적열점.
Hepatocyte nuclear factor 4α is a transcription factor of the nuclear hormone receptor superfamily and plays a very important role in the differentiation and development of the digestive system as well as the polarity regulation,which is considered to be a tumor suppressor gene.It also plays a very important role in digestive tumorigenesis,invasion and metastasis of hepatic carcinoma,colon cancer and gastric cancer,which is closely associated with epithelial-to-mesenchymal transition,the regulation of cell proliferation and wnt signaling pathway.HNF4α expression and its regulation mechanism in the digestive system tumors are now the research focus.