CAJ | 학술논문

治疗AMD的主要方法是玻璃体腔内注射抗血管内皮生长因子(VEGF)药物,但其最大的缺点是费用高、需要重复注药,一方面使经济困难的患者丧失了治疗机会,另一方面,反复眼内注射也增加了许多并发症的发生机会.因此,如何减少注药次数是该治疗最需要解决的问题.非甾体抗炎药(NSAID)具有抗炎、抗新生血管生成的作用,已有研究表明NSAID辅助抗VEGF药物治疗AMD可以提高治疗效果,减少抗VEGF药物玻璃体腔注药次数,并降低黄斑中心厚度.现对NSAID治疗CNV的机制以及动物实验和临床试验的相关研究进展进行综述,以期促进更多的眼科同仁关注此种辅助治疗方法,并开展更进一步的研究.
치료AMD적주요방법시파리체강내주사항혈관내피생장인자(VEGF)약물,단기최대적결점시비용고、수요중복주약,일방면사경제곤난적환자상실료치료궤회,령일방면,반복안내주사야증가료허다병발증적발생궤회.인차,여하감소주약차수시해치료최수요해결적문제.비치체항염약(NSAID)구유항염、항신생혈관생성적작용,이유연구표명NSAID보조항VEGF약물치료AMD가이제고치료효과,감소항VEGF약물파리체강주약차수,병강저황반중심후도.현대NSAID치료CNV적궤제이급동물실험화림상시험적상관연구진전진행종술,이기촉진경다적안과동인관주차충보조치료방법,병개전경진일보적연구.
Intravitreous injection of vascular endothelial growth factor (VEGF) inhibition is the main method of wet age-related macular degeneration (AMD) treatment.The biggest drawback of this regimen is the high cost,which make poor people lose the treatment opportunity,and repeated drug injection,which increases the incidence of a lot of complications.Therefore,how to decrease the number of drug administration is the most urgent problem to solve.Non-steroidal anti-inflammatory drugs (NSAID) have the anti-inflammation and anti-angiogenesis effects.Previous studies have shown that NSAID as an adjunctive therapy of anti-VEGF drugs for AMD can improve the treatment effect,reduce the times of intravitreous injection of VEGF drugs,and reduce the central macular thickness.Thus,the mechanism of NSAID for CNV treatment and related progress in animal experiments and clinical trials were reviewed in this paper,in order to raise concerns of more ophthalmologist about this auxiliary treatment and to promote further researches.