CAJ | 학술논문

目的：观察鼠神经生长因子（mNGF）治疗周围性面瘫的临床疗效。方法选取116例周围性面瘫患者，分为两组，实验组60例，给予mNGF肌注，对照组56例，给予甲钴胺肌注，其余治疗相同。比较治疗前后Fisch面神经分级系统综合评分及面神经功能，并总结其发病原因及年龄分布特点。结果30~50岁是周围性面瘫易发年龄，面神经炎及耳带状疱疹是主要发病原因，mNGF组的治疗痊愈率（56.7%）及总有效率（96.7%）高于对照组的治疗痊愈率（35.7%）及总有效率（85.7%），差异有统计学意义（P＜0.05）。结论鼠神经生长因子治疗周围性面瘫尤其是Bell面瘫及Hunt综合征疗效显著。
목적：관찰서신경생장인자（mNGF）치료주위성면탄적림상료효。방법선취116례주위성면탄환자，분위량조，실험조60례，급여mNGF기주，대조조56례，급여갑고알기주，기여치료상동。비교치료전후Fisch면신경분급계통종합평분급면신경공능，병총결기발병원인급년령분포특점。결과30~50세시주위성면탄역발년령，면신경염급이대상포진시주요발병원인，mNGF조적치료전유솔（56.7%）급총유효솔（96.7%）고우대조조적치료전유솔（35.7%）급총유효솔（85.7%），차이유통계학의의（P＜0.05）。결론서신경생장인자치료주위성면탄우기시Bell면탄급Hunt종합정료효현저。
Objective To observe the clinical efficacy of mouse nerve growth factor (mNGF) in the treatment of periph-eral facial paralysis. Methods A retrospective analysis was performed on 116 cases of hospitalized patients who were suffered from peripheral facial paralysis. Patients were divided into two groups according to treatment medicine , patients in mNGF group (60 cases) were treated with intramuscular mNGF, patients in control group(56 cases) were treated with intramuscular methyl-cobalamin,the other treatments were the same. The total efficiency were compared according to Fisch facial nerve grading sys-tem, and summarized the causes and age distribution characteristics. Results In the 116 cases,30~50 years old was prone to age of peripheral facial paralysis, facial neuritis and herpes zoster oticus were the main cause of disease. The cure rate and the total effective rate of mNGF group (56.7% and 96.7%) were higher than those of control group (35.7% and 85.7%), there was statistical significant differences(P<0.05). Conclusion Mouse nerve growth factor has good effect in treating peripheral facial paralysis, especially for Bell facial paralysis and Hunt syndrome.