CAJ | 학술논문

CUEDC2在肝细胞癌组织中的表达及其临床预后的意义
CUEDC2재간세포암조직중적표체급기림상예후적의의
Prognostic significance of CUEDC2 expression in hepatocellular carcino-ma

万方数据

中国病理生理杂志中國病理生理雜誌 중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2015年 1期 124-129 ,共6页

王伯庆%薛峰%丁伟%唐建军%康铁邦%毛拉艾沙·买买提%李海军%唐津天%董晓刚%尹继炜%依马木买买提江·阿布拉%易超%徐林%佟庆%张国庆

왕백경%설봉%정위%당건군%강철방%모랍애사·매매제%리해군%당진천%동효강%윤계위%의마목매매제강·아포랍%역초%서림%동경%장국경

肝肿瘤%肝切除术%CUEDC2蛋白%预后肝腫瘤%肝切除術%CUEDC2蛋白%預後
간종류%간절제술%CUEDC2단백%예후
KEY WORDS] Liver neoplasms%Hepatectomy%CUEDC2 protein%Prognosis

目的：检测含CUE结构域蛋白2（ CUEDC2）在肝细胞癌组织中的表达，探讨其与临床预后的关系。方法：选取具有完整临床及预后资料的186例手术切除肝细胞癌组织的石蜡组织标本，采用免疫组化技术检测CUEDC2的表达，并结合肝癌临床病理因素及预后进行分析。结果： CUEDC2在85.5％（159／186）的肝癌组织中有表达，其中低表达为52.2％（97／186），高表达为47.8％（89／186）；CUEDC2的表达状态与血清甲胎蛋白（AFP）水平、肿瘤大小、肿瘤数目、肝癌分化程度和TNM分期有关（P＜0.05）。 Kaplan-Meier生存分析显示CUEDC2高表达的患者术后总生存及无复发生存期较低表达者显著缩短；多因素Cox回归分析显示CUEDC2的表达状态、血清AFP和肿瘤数目是影响肝癌患者术后无复发生存（ RFS）及总生存期（ OS）的独立危险因素。结论： CUEDC2在多数肝癌组织中有表达，与肿瘤的生长、分化及预后有关；CUEDC2可以作为一个有价值的肝癌预后预测的新指标。
목적：검측함CUE결구역단백2（ CUEDC2）재간세포암조직중적표체，탐토기여림상예후적관계。방법：선취구유완정림상급예후자료적186례수술절제간세포암조직적석사조직표본，채용면역조화기술검측CUEDC2적표체，병결합간암림상병리인소급예후진행분석。결과： CUEDC2재85.5％（159／186）적간암조직중유표체，기중저표체위52.2％（97／186），고표체위47.8％（89／186）；CUEDC2적표체상태여혈청갑태단백（AFP）수평、종류대소、종류수목、간암분화정도화TNM분기유관（P＜0.05）。 Kaplan-Meier생존분석현시CUEDC2고표체적환자술후총생존급무복발생존기교저표체자현저축단；다인소Cox회귀분석현시CUEDC2적표체상태、혈청AFP화종류수목시영향간암환자술후무복발생존（ RFS）급총생존기（ OS）적독립위험인소。결론： CUEDC2재다수간암조직중유표체，여종류적생장、분화급예후유관；CUEDC2가이작위일개유개치적간암예후예측적신지표。
AIM:To investigate the expression of CUE domain-containing 2 (CUEDC2) in hepatocellular car-cinoma ( HCC) and to analyze its clinical prognostic significance .METHODS:Total 186 formalin-fixed paraffin-embed-ded tissues obtained from surgical HCC with detailed clinicopathological and follow -up data were used .The expression of CUEDC2 was detected by immunohistochemistry .The relationships between the expression of CUEDC 2 and clinicopatholog-ical characteristics and prognosis were analyzed .RESULTS: The positive rate of CUEDC 2 in HCC was 85.5% ( 159/186), among which, the low expression was 52.2%(97/186) and the high expression was 47.8%(89/186).CUEDC2 expression was correlated with serum alpha-fetal protein (AFP) level, tumor size, tumor number, tumor differentiation and TNM stage (P<0.05).Kaplan-Meier survival curves showed that the patients with high expression of CUEDC 2 were asso-ciated with significantly shorter overall survival and recurrence-free survival than those with low CUEDC 2 expression ( P<0.05).Multivariate Cox regression analysis revealed 3 independent prognostic factors including CUEDC 2 expression, ser-um AFP and tumor number .CONCLUSION:CUEDC2 was expressed in most HCC tissues , which was relevant to tumor growth, tumor differentiation and prognosis .CUEDC2 could be a novel valuable molecular marker to predict the HCC prog-nosis.