CAJ | 학술논문

目的：探讨疏血通注射液联合低分子肝素及华法令抗凝治疗肺栓塞的临床疗效及安全性。方法选取急性肺栓塞住院患者81例，分为2组：疏血通联合低分子肝素、华法令治疗组为试验组，共48例；低分子肝素及华法令治疗组为对照组，共33例。通过比较2组治疗后临床症状，血气分析结果，肺动脉CT或核素通气/灌注恢复情况，了解治疗效果。通过比较凝血指标，了解治疗的安全性。结果治疗7 d，试验组临床症状改善率为83.33%，对照组为66.64%，2组比较差异有统计学意义。治疗14 d临床症状改善情况及通气指标，凝血指标比较，2组均无显著差异。结论疏血通联合抗凝治疗在治疗7d的临床症状改善方面优于单纯抗凝治疗组，且治疗安全性好。
목적：탐토소혈통주사액연합저분자간소급화법령항응치료폐전새적림상료효급안전성。방법선취급성폐전새주원환자81례，분위2조：소혈통연합저분자간소、화법령치료조위시험조，공48례；저분자간소급화법령치료조위대조조，공33례。통과비교2조치료후림상증상，혈기분석결과，폐동맥CT혹핵소통기/관주회복정황，료해치료효과。통과비교응혈지표，료해치료적안전성。결과치료7 d，시험조림상증상개선솔위83.33%，대조조위66.64%，2조비교차이유통계학의의。치료14 d림상증상개선정황급통기지표，응혈지표비교，2조균무현저차이。결론소혈통연합항응치료재치료7d적림상증상개선방면우우단순항응치료조，차치료안전성호。
Objective To investigate the clinical efficiency and safety of Shuxuetong Injection combined with low molecular hepa?rin and warfarin for treating pulmonary embolism. Methods Eighty-one patients with acute pulmonary embolism, were randomly divid?ed into treatment and control groups. The patients in the treatment group were treated with Shuxuetong Injection combined low molecu?lar heparin and warfarin, and those in the control group were treated with low molecular heparin and warfarin. Clinical symptoms ( such as dyspnea and chest pain ), results of the blood-gas analysis, images of CT of pulmonary artery or ventilation and perfusion scintigra?phy in the patients were compared after treatment between the different groups to measure treatment effect, coagulation indices used to evaluate safety. Results Seven days after treatment, ameliorative rate of symptom in treatment group was 83.33%, and in control groups was 66.64%. There were significant differences between each other. Fourteen days after treatment, ameliorative rate of symptom, venti?late indices and coagulation indices between the 2 groups were not obviously different. Conclusion The method of Shuxuetong Injec?tion combined with low molecular heparin and warfarin is better than pure anticoagulation at improving symptoms after seven days’ treatment and possesses good safety.