CAJ | 학술논문

癫痫是一种慢性反复发作性疾病，经正规治疗仍有20%～30%患者对抗癫痫药物耐药而发展成为难治性癫痫，进而求助于手术、生物疗法，但这些方法价格昂贵、疗效不确定。明确癫痫的耐药机制，发展新型的神经治疗措施是大势所趋。现就癫痫的耐药机制作一综述。
전간시일충만성반복발작성질병，경정규치료잉유20%～30%환자대항전간약물내약이발전성위난치성전간，진이구조우수술、생물요법，단저사방법개격앙귀、료효불학정。명학전간적내약궤제，발전신형적신경치료조시시대세소추。현취전간적내약궤제작일종술。
Epilepsy is a chronic, recurrent paroxysmal disease. About 20%-30% of epilepsy patients are resistant to anti-epilepsy drugs after rational therapy. Finding another way to treat this disease, such as surgery and physiotherapy is expensive and the efficacy is unknown. It’s necessary to develop new neurological strategies according to the mechanism of drug-resistance in epilepsy, which was reviewed in this paper.