CAJ | 학술논문

目的：探讨新癀片及其中药组分对次黄嘌呤所致的高尿酸小鼠的影响，并初步探讨其机制。方法采用腹腔注射次黄嘌呤引起的高尿酸小鼠动物模型和正常小鼠，分别以新癀片及其中药组分不同剂量组进行灌胃，给药结束后测定血尿酸水平以及肝脏中黄嘌呤氧化酶活性。结果腹腔注射次黄嘌呤1h后，阳性组、新癀片低中高剂量组（23．75、47．5、95mg? kg －1）、新癀片中药组分低中高剂量组（23．75、47．5、95mg?kg－1），能明显对抗次黄嘌呤引起的高尿酸作用（P＜0．01），且对肝脏中黄嘌呤氧化酶的活性有一定程度的抑制作用。结论新癀片及其中药组分可能通过抑制黄嘌呤氧化酶的活性来降低血尿酸水平。
목적：탐토신황편급기중약조분대차황표령소치적고뇨산소서적영향，병초보탐토기궤제。방법채용복강주사차황표령인기적고뇨산소서동물모형화정상소서，분별이신황편급기중약조분불동제량조진행관위，급약결속후측정혈뇨산수평이급간장중황표령양화매활성。결과복강주사차황표령1h후，양성조、신황편저중고제량조（23．75、47．5、95mg? kg －1）、신황편중약조분저중고제량조（23．75、47．5、95mg?kg－1），능명현대항차황표령인기적고뇨산작용（P＜0．01），차대간장중황표령양화매적활성유일정정도적억제작용。결론신황편급기중약조분가능통과억제황표령양화매적활성래강저혈뇨산수평。
ABSTRACT:OBJECTIVE To investigate effect of Xinhuang tablets and its Chinese medicine components on high uric acid Mice Caused by hypoxanthine , and discusse its mechanism .METHODS The mice models of high uric acid caused by injecting hypoxanthine and the normal mice were adopted .After giving different doses of intragastric administration with extracts from Xinhuang tablets and its Chinese medicine components on the mice by gavage ,the uric and xanthine oxidase level of each group were determined .RESULTS After 1h of intraperitoneal injection of hypoxanthine ,positive control group and Xinhuang tablets and its Chinese medicine components dosage ( 23.75、47.5、95 mg? kg -1 ) could against high uric mice induced by hypoxanthine and reduced the activity of xanthine oxi -dase in hepar ( P<0.01 ) .CONCLUSION Xinhuang tablets and its Chinese medicine components could decrese the blood uric acid levels by inhibiting the activity of xanthine oxidase .