中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
4期
547-550
,共4页
李菁%黄东辉%唐先格%郭征东
李菁%黃東輝%唐先格%郭徵東
리정%황동휘%당선격%곽정동
糖尿病,2型%心肌疾病%氧化性应激%糖基化终末产物
糖尿病,2型%心肌疾病%氧化性應激%糖基化終末產物
당뇨병,2형%심기질병%양화성응격%당기화종말산물
Diabetes mellitus,type 2%Cardiomyopathies%Oxidative stress%Advanced glycation end products
目的：研究氧化应激因素和糖基化终末产物（AGEs）在2型糖尿病（T2DM）心肌病变（DCM）的作用及其相关性。方法选择泰安地区的T2DM患者78例，根据超声心动图、冠状动脉造影等情况，分为单纯T2DM组40例，DCM组38例，另选取正常对照组（NC）40例。测定超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）以及谷胱甘肽过氧化物酶（GHS-PX）等氧化应激指标和糖基化终末产物（AGEs），进行数据统计，并进行相关性分析。结果 T2DM组SOD、NO、GHS-PX较NC组均明显下降，MDA、AGEs则较NC组均明显升高；而DCM组较T2DM组SOD、GHS-PX 明显下降，MDA、AGEs 明显升高，差异均有统计学意义（P＜0.01），而血清 NO水平T2DM组较NC组下降，DCM组再次升高，且高于NC组，差异均有统计学意义（P＜0.01）。结论氧化应激因素和AGEs在DCM的进展中均有重要作用，促进DCM的发生和发展，且二者之间有相关性，SOD的下降和MDA的升高是AGEs的独立相关因素。
目的：研究氧化應激因素和糖基化終末產物（AGEs）在2型糖尿病（T2DM）心肌病變（DCM）的作用及其相關性。方法選擇泰安地區的T2DM患者78例，根據超聲心動圖、冠狀動脈造影等情況，分為單純T2DM組40例，DCM組38例，另選取正常對照組（NC）40例。測定超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）以及穀胱甘肽過氧化物酶（GHS-PX）等氧化應激指標和糖基化終末產物（AGEs），進行數據統計，併進行相關性分析。結果 T2DM組SOD、NO、GHS-PX較NC組均明顯下降，MDA、AGEs則較NC組均明顯升高；而DCM組較T2DM組SOD、GHS-PX 明顯下降，MDA、AGEs 明顯升高，差異均有統計學意義（P＜0.01），而血清 NO水平T2DM組較NC組下降，DCM組再次升高，且高于NC組，差異均有統計學意義（P＜0.01）。結論氧化應激因素和AGEs在DCM的進展中均有重要作用，促進DCM的髮生和髮展，且二者之間有相關性，SOD的下降和MDA的升高是AGEs的獨立相關因素。
목적：연구양화응격인소화당기화종말산물（AGEs）재2형당뇨병（T2DM）심기병변（DCM）적작용급기상관성。방법선택태안지구적T2DM환자78례，근거초성심동도、관상동맥조영등정황，분위단순T2DM조40례，DCM조38례，령선취정상대조조（NC）40례。측정초양화물기화매（SOD）、병이철（MDA）、일양화담（NO）이급곡광감태과양화물매（GHS-PX）등양화응격지표화당기화종말산물（AGEs），진행수거통계，병진행상관성분석。결과 T2DM조SOD、NO、GHS-PX교NC조균명현하강，MDA、AGEs칙교NC조균명현승고；이DCM조교T2DM조SOD、GHS-PX 명현하강，MDA、AGEs 명현승고，차이균유통계학의의（P＜0.01），이혈청 NO수평T2DM조교NC조하강，DCM조재차승고，차고우NC조，차이균유통계학의의（P＜0.01）。결론양화응격인소화AGEs재DCM적진전중균유중요작용，촉진DCM적발생화발전，차이자지간유상관성，SOD적하강화MDA적승고시AGEs적독립상관인소。
Objective To study the affection and relationship of oxidative stress and advanced glycation end products (AGEs) in diabetic cardiomyopathy (DCM). Methods 78 T2DM patients in Tai’an area were categorizer into two groups based on cardiac color ultrasound and coronary angiogram:38 cases with DCM, 40 cases T2DM without complications, another 40 subject without T2DM as control group. After measuring oxidative stress indicator such as SOD, MDA, NO, GHS-PX and AGEs, all the data were taken into statistics. Results There was a significant lower SOD, NO, GHS-PX levels and higher MDA, AGEs levels in T2DM group compared to NC group. In the same way, the SOD, NO, GHS-PX levels were significantly lower in DCM group compared to T2DM group and MDA, AGEs levels were significantly higher in DCM group compared to T2DM group (P<0.01). The NO level in T2DM group were lower than NC group, it was also significantly lower compared to DCM group as a oxidative stress indicator (P<0.01). Conclusion Oxidative stress and AGEs were important factor in DCM and aggravate it’s progress, SOD and MDA were exclusively correlative factor for AGEs.
