海峡药学
海峽藥學
해협약학
STRAIT PHARMACEUTICAL JOURNAL
2015年
1期
33-35
,共3页
谢升谷%郑国钢%陶巧凤%洪利娅%张启明
謝升穀%鄭國鋼%陶巧鳳%洪利婭%張啟明
사승곡%정국강%도교봉%홍리아%장계명
萘普生%萘普生胶囊%HPLC%异构体
萘普生%萘普生膠囊%HPLC%異構體
내보생%내보생효낭%HPLC%이구체
Naproxen%Naproxen capsules%HPLC%Enantiomer
目的:探讨萘普生与萘普生胶囊中异构体的含量。方法采用HPLC法,以手性色谱柱为分离柱,测定异构体的含量。结果 L-萘普生峰与D-萘普生峰的分离度良好,溶液在12h内稳定;4批样品的异构体含量为0.5%~0.7%。结论本方法简便、准确性好、灵敏度高,可以有效地测定萘普生与萘普生胶囊中异构体含量。
目的:探討萘普生與萘普生膠囊中異構體的含量。方法採用HPLC法,以手性色譜柱為分離柱,測定異構體的含量。結果 L-萘普生峰與D-萘普生峰的分離度良好,溶液在12h內穩定;4批樣品的異構體含量為0.5%~0.7%。結論本方法簡便、準確性好、靈敏度高,可以有效地測定萘普生與萘普生膠囊中異構體含量。
목적:탐토내보생여내보생효낭중이구체적함량。방법채용HPLC법,이수성색보주위분리주,측정이구체적함량。결과 L-내보생봉여D-내보생봉적분리도량호,용액재12h내은정;4비양품적이구체함량위0.5%~0.7%。결론본방법간편、준학성호、령민도고,가이유효지측정내보생여내보생효낭중이구체함량。
ABSTRACT:OBJECTIVE To discuss on enantiomer content in Naproxen and its capsules .METHODS The content of naproxen enantiomer was determined by HPLC method using chiral column .RESULTS The resolution of L-naproxen and D-naproxen was good .The solution was stable in 12 hours.The contents of naproxen enantiomer in four batches samples were between 0.5%to 0.7%.CONCLUSION The method is convenient ,accurate and sensi-tive to be used for determination of enantiomer content in naproxen and its capsules .