CAJ | 학술논문

黑色素瘤是皮肤癌中最具侵袭性、死亡率较高的恶性肿瘤。Ⅰ、Ⅱ期黑色素瘤采取手术切除可完全治愈，Ⅲ、Ⅳ期黑色素瘤应用传统的手术、放化疗方案治疗效果不理想，预后差。近年来，随着对Ⅲ、Ⅳ期黑色素瘤治疗方案的探索，靶向免疫治疗取得了显著疗效。靶向免疫药物可抑制负性调节因子，增强全身抗肿瘤免疫效应。放疗在杀死局部肿瘤的同时，也可增强全身免疫应答。近期研究发现，靶向免疫联合放射治疗可增强对肿瘤局部和远处的控制作用，延长患者总体生存期，两者联合治疗优于单一治疗方案。本文对上述研究领域内的进展进行综述。
흑색소류시피부암중최구침습성、사망솔교고적악성종류。Ⅰ、Ⅱ기흑색소류채취수술절제가완전치유，Ⅲ、Ⅳ기흑색소류응용전통적수술、방화료방안치료효과불이상，예후차。근년래，수착대Ⅲ、Ⅳ기흑색소류치료방안적탐색，파향면역치료취득료현저료효。파향면역약물가억제부성조절인자，증강전신항종류면역효응。방료재살사국부종류적동시，야가증강전신면역응답。근기연구발현，파향면역연합방사치료가증강대종류국부화원처적공제작용，연장환자총체생존기，량자연합치료우우단일치료방안。본문대상술연구영역내적진전진행종술。
Melanoma is the most aggressive and lethal malignant tumor in skin cancers. Operation resection is used to treat stageⅠ/Ⅱmelanomas, but traditional operation, chemotherapy, and radiotherapy inflicts adverse effects on late-stage melanomas. StageⅢ/Ⅳmelanomas are some of the most ineffectively treated tumors with poor prognosis. As a cancer treatment, targeted immunotherapy in-hibits negative regulatory factors and enhances systemic anti-tumor immune effects. Radiotherapy not only kills tumor cells, but also en-hances systemic immune responses. Recent studies showed that targeted immunotherapy combined with radiotherapy can promote con-trol on local and distant tumors and prolong overall survival. The synergistic effects of these two therapies are superior to a single thera-py. This review summarized the progress on these research fields.