CAJ | 학술논문

近年来儿童恶性肿瘤的发病率有逐年增高的趋势，高危患儿预后差，且手术及放化疗等主要治疗手段的疗效已经达到平台期。靶向治疗以其可靠的疗效和轻微的毒副反应成为目前最受关注和最有前景的治疗手段之一。间变性淋巴瘤激酶（an?aplastic lymphoma kinase，ALK）是一种受体型酪氨酸激酶，近年的研究成果表明其异常与多种儿童肿瘤的发生发展密切相关。ALK的异常形式主要包括基因融合、基因突变、基因扩增和蛋白表达增加。随着ALK抑制剂在临床抗肿瘤治疗中的应用，针对ALK异常的靶向治疗获得越来越多的关注。本研究主要针对ALK在儿童恶性肿瘤中的异常以及与其发生发展关系的研究进展进行综述。
근년래인동악성종류적발병솔유축년증고적추세，고위환인예후차，차수술급방화료등주요치료수단적료효이경체도평태기。파향치료이기가고적료효화경미적독부반응성위목전최수관주화최유전경적치료수단지일。간변성림파류격매（an?aplastic lymphoma kinase，ALK）시일충수체형락안산격매，근년적연구성과표명기이상여다충인동종류적발생발전밀절상관。ALK적이상형식주요포괄기인융합、기인돌변、기인확증화단백표체증가。수착ALK억제제재림상항종류치료중적응용，침대ALK이상적파향치료획득월래월다적관주。본연구주요침대ALK재인동악성종류중적이상이급여기발생발전관계적연구진전진행종술。
In recent years, the incidence of pediatric malignancies has gradually increased. High-risk patients have poor prognosis, and the main effect of treatments such as surgery and radio-chemotherapy has reached a plateau phase. Targeted therapy, with its reliable efficacy and mild toxicity, has become one of the most promising approaches. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, and its abnormal forms include gene fusion, gene mutation, gene amplification, and protein overexpression. These aberrations play important roles in the development of childhood cancer. With the application of ALK inhibitors in clinical anti-tumor therapy, targeted ALK treatment has received increased attention. This article aims to review various studies on the relationship between ALK aberrations and pediatric malignancies.