中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2015年
1期
59-61
,共3页
唐慧敏%杨文林%黄桃源%尹嘉文%杨健
唐慧敏%楊文林%黃桃源%尹嘉文%楊健
당혜민%양문림%황도원%윤가문%양건
荨麻疹%前白蛋白%转铁蛋白%胰岛素样生长因子结合蛋白质1%肿瘤坏死因子-α
蕁痳疹%前白蛋白%轉鐵蛋白%胰島素樣生長因子結閤蛋白質1%腫瘤壞死因子-α
담마진%전백단백%전철단백%이도소양생장인자결합단백질1%종류배사인자-α
Urticaria%Prealbumin%Transferrin%Insulin-like growth factor binding protein 1%Tumor necrosis factor-α
目的 探讨急性时相反应与慢性荨麻疹的关系.方法 慢性荨麻疹患者50例,按症状分为轻型(1级)、中型(2级)、重型(3级)3组,同时选取健康体检者28例,用免疫比浊法测定血清前白蛋白(PA)、转铁蛋白(TRF)水平,采用酶联免疫吸附法测定胰岛素样生长因子1(IGF-1)和肿瘤坏死因子α(TNF-α)水平;比较两组之间的差异、各检测项目之间的相关性及与病情分级的关系.结果 慢性荨麻疹患者PA(229.99±54.16) mg/L、IGF-1 (177.23±46.48) μg/L均明显低于健康对照组,两组差异有统计学意义(均P＜0.05).TNF-α(25.39±11.01) ng/L高于健康对照组(14.13±6.12) ng/L,差异有统计学意义(P＜0.05).TRF水平(2.48±0.49) g/L与健康对照组(2.48±0.25) g/L比较,差异无统计学意义(P＞0.05).血清PA与TNF-α呈显著负相关(P＜0.05),并与病情严重程度呈显著负相关(P＜0.01),而TNF-α则与病情严重程度呈显著正相关(P＜0.01);其余各指标之间无明显相关性(均P＞0.05).结论 在慢性荨麻疹患者中,部分急性时相反应负性蛋白水平降低且与病情呈负相关,急性时相反应可能参与慢性荨麻疹的发病.
目的 探討急性時相反應與慢性蕁痳疹的關繫.方法 慢性蕁痳疹患者50例,按癥狀分為輕型(1級)、中型(2級)、重型(3級)3組,同時選取健康體檢者28例,用免疫比濁法測定血清前白蛋白(PA)、轉鐵蛋白(TRF)水平,採用酶聯免疫吸附法測定胰島素樣生長因子1(IGF-1)和腫瘤壞死因子α(TNF-α)水平;比較兩組之間的差異、各檢測項目之間的相關性及與病情分級的關繫.結果 慢性蕁痳疹患者PA(229.99±54.16) mg/L、IGF-1 (177.23±46.48) μg/L均明顯低于健康對照組,兩組差異有統計學意義(均P＜0.05).TNF-α(25.39±11.01) ng/L高于健康對照組(14.13±6.12) ng/L,差異有統計學意義(P＜0.05).TRF水平(2.48±0.49) g/L與健康對照組(2.48±0.25) g/L比較,差異無統計學意義(P＞0.05).血清PA與TNF-α呈顯著負相關(P＜0.05),併與病情嚴重程度呈顯著負相關(P＜0.01),而TNF-α則與病情嚴重程度呈顯著正相關(P＜0.01);其餘各指標之間無明顯相關性(均P＞0.05).結論 在慢性蕁痳疹患者中,部分急性時相反應負性蛋白水平降低且與病情呈負相關,急性時相反應可能參與慢性蕁痳疹的髮病.
목적 탐토급성시상반응여만성담마진적관계.방법 만성담마진환자50례,안증상분위경형(1급)、중형(2급)、중형(3급)3조,동시선취건강체검자28례,용면역비탁법측정혈청전백단백(PA)、전철단백(TRF)수평,채용매련면역흡부법측정이도소양생장인자1(IGF-1)화종류배사인자α(TNF-α)수평;비교량조지간적차이、각검측항목지간적상관성급여병정분급적관계.결과 만성담마진환자PA(229.99±54.16) mg/L、IGF-1 (177.23±46.48) μg/L균명현저우건강대조조,량조차이유통계학의의(균P＜0.05).TNF-α(25.39±11.01) ng/L고우건강대조조(14.13±6.12) ng/L,차이유통계학의의(P＜0.05).TRF수평(2.48±0.49) g/L여건강대조조(2.48±0.25) g/L비교,차이무통계학의의(P＞0.05).혈청PA여TNF-α정현저부상관(P＜0.05),병여병정엄중정도정현저부상관(P＜0.01),이TNF-α칙여병정엄중정도정현저정상관(P＜0.01);기여각지표지간무명현상관성(균P＞0.05).결론 재만성담마진환자중,부분급성시상반응부성단백수평강저차여병정정부상관,급성시상반응가능삼여만성담마진적발병.
Objective To investigate the relationship between negative acute phase proteins and chronic urticaria (CU).Methods Fifty patients with CU were enrolled into this study,and divided into three grades,i.e.,mild (grade 1),moderate (grade 2) and severe (grade 3) according to symptoms.Twenty-eight health checkup examinees served as the control group.Immunoturbidimetry was performed to determine serum levels of prealbumin (PA) and transferrin (TRF).Enzyme-linked immunosorbent assay was conducted to measure serum levels of insulinlike growth factor-1 (IGF-1) and tumor necrosis factor-α (TNF-α).Statistical analysis was carried out to assess differences in these indices between these two groups,the relationship among these indices and between these indices and disease severity.Results Compared with the control group,the patients with CU showed reduced serum levels of PA ((229.99 ± 54.16) vs.(272.06 ± 36.42) mg/L,t =3.667,P ＜ 0.05) and IGF-1 ((177.23 ± 46.48) vs.(239.88 ± 45.16) μg/L,t =5.748,P＜ 0.05),but higher serum levels of TNF-α ((25.39 ± 11.01) vs.(14.13 ± 6.12) ng/L,t =4.989,P＜ 0.05),and similar serum levels of TRF ((2.48 ± 0.49) vs.(2.48 ± 0.25) g/L,P＞ 0.05).The serum level of PA showed a significant negative correlation with that of TNF-α (r =-0.312,P ＜ 0.05),as well as with disease severity (r =-0.635,P ＜ 0.01),whereas the serum level of TNF-α showed a significant positive correlation with disease severity (r =0.409,P ＜ 0.01),and no statistical correlation was found between the remaining indices (all P ＞ 0.05) in the patients with CU.Conclusions Serum levels of some negative acute phase proteins decrease and negatively correlate with disease severity in patients with CU.Acute phase response may be involved in the occurrence of CU.
