CAJ | 학술논문

维生素A缺乏是哮喘发病的危险因素之一.维生素A具有拮抗气道氧化性损伤、促进气道损伤的修复、抑制气道高反应、诱导免疫耐受、调节气道炎症等功能.维生素A用于哮喘防治成为研究热点,但其效益性仍存在争议.维生素A的受体广泛表达、信号通路复杂,维生素A与哮喘发病相关机制有待更深入的研究.目前,维生素A用于哮喘防治的临床研究已有报道,但结果尚不一致.哮喘是一种由环境和遗传因素共同作用的多基因遗传病,今后维生素A用于哮喘防治的基础和临床研究可结合遗传和环境的群体差异.该文就维生素A与哮喘关系的研究进展进行综述.
유생소A결핍시효천발병적위험인소지일.유생소A구유길항기도양화성손상、촉진기도손상적수복、억제기도고반응、유도면역내수、조절기도염증등공능.유생소A용우효천방치성위연구열점,단기효익성잉존재쟁의.유생소A적수체엄범표체、신호통로복잡,유생소A여효천발병상관궤제유대경심입적연구.목전,유생소A용우효천방치적림상연구이유보도,단결과상불일치.효천시일충유배경화유전인소공동작용적다기인유전병,금후유생소A용우효천방치적기출화림상연구가결합유전화배경적군체차이.해문취유생소A여효천관계적연구진전진행종술.
Vitamin A deficiency is a risk factor for asthma.Vitamin A plays important roles in maintaining airway epithelium phenotype,suppressing airway hyperresponsiveness,inducing immune tolerance and regulating airway inflammation,etc.The value of Vitamin A in asthma prevention and treatment has received wild attention but is still controverial.Vitamin A receptors are wildly expressed and the mechanisms are complex,more studies are needed to further clarify the relationship between Vitamin A and asthma.Besides,asthma is a polygenetic disease caused by environmental and genetic factors,and the current clinical studies of Vitamin A for prevention and treatment of asthma are not consistent.New epidemiologic studies about Vitamin A and asthma should take environmental and genetic factors into consideration.This article gives an overview about the research progress of the relationship between Vitamin A and asthma.