国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2015年
1期
11-14
,共4页
儿童%抽动秽语综合征%细胞因子%辅助性T细胞
兒童%抽動穢語綜閤徵%細胞因子%輔助性T細胞
인동%추동예어종합정%세포인자%보조성T세포
Children%Tourette syndrome%Cytokines%Helper T cell
近年来抽动秽语综合征(Tourette syndrome,TS)患病率逐渐增高,但发病机制仍不清楚.一些研究提示TS患儿存在非特异和特异性免疫的异常,如辅助性T细胞亚群Th1和Th2紊乱,以及所分泌的细胞因子水平的变化、自然杀伤细胞和自身抗体表达的改变等.免疫系统的动态平衡和适度的免疫应答对维持机体正常生理功能发挥重要作用.该文对TS患儿免疫特点进行综述,探讨免疫功能紊乱对TS患儿发病的影响,为临床诊断及治疗提供理论依据.
近年來抽動穢語綜閤徵(Tourette syndrome,TS)患病率逐漸增高,但髮病機製仍不清楚.一些研究提示TS患兒存在非特異和特異性免疫的異常,如輔助性T細胞亞群Th1和Th2紊亂,以及所分泌的細胞因子水平的變化、自然殺傷細胞和自身抗體錶達的改變等.免疫繫統的動態平衡和適度的免疫應答對維持機體正常生理功能髮揮重要作用.該文對TS患兒免疫特點進行綜述,探討免疫功能紊亂對TS患兒髮病的影響,為臨床診斷及治療提供理論依據.
근년래추동예어종합정(Tourette syndrome,TS)환병솔축점증고,단발병궤제잉불청초.일사연구제시TS환인존재비특이화특이성면역적이상,여보조성T세포아군Th1화Th2문란,이급소분비적세포인자수평적변화、자연살상세포화자신항체표체적개변등.면역계통적동태평형화괄도적면역응답대유지궤체정상생리공능발휘중요작용.해문대TS환인면역특점진행종술,탐토면역공능문란대TS환인발병적영향,위림상진단급치료제공이론의거.
In recent years,the incidence of Tourette syndrome (TS) has been increasing,but the pathogenesis of TS was unclear.Immune abnormalities were reported in some children with TS,who had abnormal levels of helper T cell subgroup Th1/Th2,cytokines,natural killer cells and autoantibodies expression.Balance and moderation of the immune play an important role in maintaining the physiological functioning normally.To study the status of immune in children with TS is conducive to manage strategies of treatment.
