CAJ | 학술논문

尿路感染(urinary tract infection,UTI)是儿童期多发病,随着广谱抗生素的大量使用,耐药菌株逐年增多,尤以大肠埃希菌(Escherichia coli,E.coli)为著.E.coli耐药机制有产生药物水解酶、靶基因突变、主动外排泵和膜通透性的改变等,其中产超广谱β-内酰胺酶(extended spectrum beta-lactamases,ESBL)E.coli日趋增多,给临床抗生素的选择提出了巨大挑战.根据其耐药基因(blaTEM、blaSHV、blaCTX-M等)的不同分为不同类型(TEM型、SHV型、CTX-M型等)的ESBL.各种类型的ESBL对耐药基因的传播和流行起重要的作用,该文对目前已知耐药基因型的现状作一综述.
뇨로감염(urinary tract infection,UTI)시인동기다발병,수착엄보항생소적대량사용,내약균주축년증다,우이대장애희균(Escherichia coli,E.coli)위저.E.coli내약궤제유산생약물수해매、파기인돌변、주동외배빙화막통투성적개변등,기중산초엄보β-내선알매(extended spectrum beta-lactamases,ESBL)E.coli일추증다,급림상항생소적선택제출료거대도전.근거기내약기인(blaTEM、blaSHV、blaCTX-M등)적불동분위불동류형(TEM형、SHV형、CTX-M형등)적ESBL.각충류형적ESBL대내약기인적전파화류행기중요적작용,해문대목전이지내약기인형적현상작일종술.
Urinary tract infections (UTI)is a childhood disease.With the use of extended spectrum antibiotics,resistant strains have increased every year,especially Escherichia coli(E.coli).The mechanisms of drug resistance are as follows:hydrolase,target gene mutations,efflux pumps and membrane permeability change.Of which producing extended-spectrum β-lactamase(ESBL) is increasing.So it presents a huge challenge to clinical antibiotic selection.According to the resistance genes (blaTEM,blaSHV,blaCTX-M,etc.),the ESBL can be classified into different types (TEM type,SHV-type,CTX-M type,etc.).The drug-resistant genes play an important role in spreading and prevalence of the resistance genes.It's necessary to do a review of the currently known genotypes.It is both in favor of scientific research work and providing guidance for clinical work.