国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2015年
1期
28-30,34
,共4页
干扰素调节因子-5%干扰素%系统性红斑狼疮%肿瘤
榦擾素調節因子-5%榦擾素%繫統性紅斑狼瘡%腫瘤
간우소조절인자-5%간우소%계통성홍반랑창%종류
Interferon regulatory factor 5%Interferon%Systemic lupus erythematosus%Tumor
干扰素调节因子-5能诱导IFN-α、IFN-β产生,也能促进IL-6、IL-12b、IL-17、IL-23、TNF等细胞因子的分泌,从而参与机体的免疫反应、细胞生长、细胞分化、细胞凋亡、肿瘤发生和细胞信号转导等过程.干扰素调节因子-5在人体许多疾病的发生、发展中起重要作用.深入研究干扰素调节因子-5有助于我们可以更好地阐明相关疾病的发病机制并为治疗这些相关疾病提供理论依据和相应的靶点.
榦擾素調節因子-5能誘導IFN-α、IFN-β產生,也能促進IL-6、IL-12b、IL-17、IL-23、TNF等細胞因子的分泌,從而參與機體的免疫反應、細胞生長、細胞分化、細胞凋亡、腫瘤髮生和細胞信號轉導等過程.榦擾素調節因子-5在人體許多疾病的髮生、髮展中起重要作用.深入研究榦擾素調節因子-5有助于我們可以更好地闡明相關疾病的髮病機製併為治療這些相關疾病提供理論依據和相應的靶點.
간우소조절인자-5능유도IFN-α、IFN-β산생,야능촉진IL-6、IL-12b、IL-17、IL-23、TNF등세포인자적분비,종이삼여궤체적면역반응、세포생장、세포분화、세포조망、종류발생화세포신호전도등과정.간우소조절인자-5재인체허다질병적발생、발전중기중요작용.심입연구간우소조절인자-5유조우아문가이경호지천명상관질병적발병궤제병위치료저사상관질병제공이론의거화상응적파점.
Interferon regulatory factor 5 (IRF-5) can induce the expressions of IFN-α,IFN-β and promote the secretion of cytokines,including IL-6,IL-12 b,IL-17,IL-23,TNF etc.IRF-5 is involved in the process of immune response,cell growth,cell differentiation,cell apoptosis,tumorigenesis and cell signal transduction.For that reason,IRF-5 plays an important role in the occurrence and progress of many diseases in humans.Further studies of IRF-5 will better elucidate the pathogenesis of related diseases and provide theoretical basis for treatment of these diseases and the corresponding therapeutic targets.
