CAJ | 학술논문

细菌性脑膜炎是小儿时期最常见的中枢神经系统感染性疾病之一,尽管给予积极治疗,其病死率及致残率仍居高不下.研究表明,病原感染后导致宿主免疫失调是该病高致残率的主要因素.补体C3沉积细菌表面并活化是补体介导的细菌清除的关键步骤.脑脊液中C3或C5水平明显变化提示预后不良.致病菌穿过血脑屏障后,细菌细胞组分被模式识别受体识别,刺激机体产生过量细胞因子,介导白细胞募集及氧化应激反应,最终导致神经元不可逆损伤.该文以肺炎链球菌感染为例,综述细菌性脑膜炎的免疫学研究进展.
세균성뇌막염시소인시기최상견적중추신경계통감염성질병지일,진관급여적겁치료,기병사솔급치잔솔잉거고불하.연구표명,병원감염후도치숙주면역실조시해병고치잔솔적주요인소.보체C3침적세균표면병활화시보체개도적세균청제적관건보취.뇌척액중C3혹C5수평명현변화제시예후불량.치병균천과혈뇌병장후,세균세포조분피모식식별수체식별,자격궤체산생과량세포인자,개도백세포모집급양화응격반응,최종도치신경원불가역손상.해문이폐염련구균감염위례,종술세균성뇌막염적면역학연구진전.
Bacterial meningitis is one of the most common infectious diseases of the central nervous system in childhood,with high mortality and disability rate despite available treatment.Studies have shown that the host's immunity dysfunction after the infection plays a central role in neurological sequelae.The deposition and activation of complement component C3 on the bacterial surface is a key step in the complement cascade leading to elimination of the microbe,and the level of complement component C3 or C5 in cerebrospinal fluid may predict outcome of bacterial meningitis.After the microorganisms cross the blood-brain barrier,bacterial compounds are recognized by pattern recognition receptors,triggering the production of excessive cytokines,attracting leukocytes and generating oxidative stress,which contributes to neuron injury irreversibly.This review focuses on current research progress on immunology associated with pneumococcal meningitis.