CAJ | 학술논문

炎症反应、免疫抑制、氧化应激等是脓毒症的主要致病机制.近年来研究发现,ω-3多不饱和脂肪酸(ω-3 polyunsaturated fatty acid,ω-3PUFA)可通过多种途径与花生四烯酸竞争,减少其代谢产物;通过改变细胞膜信号平台“脂筏”的性质、通过其代谢产物参与炎症的消退与组织修复,降低NF-κB的激活,抑制炎症反应.ω-3PUFA还能改善机体的抗氧化防御系统,减轻氧化应激.目前临床研究证实ω-3 PUFA能有效治疗脓毒症患者.该文就ω-3PUFA治疗脓毒症的具体机制作一综述.
염증반응、면역억제、양화응격등시농독증적주요치병궤제.근년래연구발현,ω-3다불포화지방산(ω-3 polyunsaturated fatty acid,ω-3PUFA)가통과다충도경여화생사희산경쟁,감소기대사산물;통과개변세포막신호평태“지벌”적성질、통과기대사산물삼여염증적소퇴여조직수복,강저NF-κB적격활,억제염증반응.ω-3PUFA환능개선궤체적항양화방어계통,감경양화응격.목전림상연구증실ω-3 PUFA능유효치료농독증환자.해문취ω-3PUFA치료농독증적구체궤제작일종술.
Inflammation,immune suppression and oxidative stress is the main pathogenesis of sepsis.In recent years,more study have found ω-3 polyunsaturated fatty acid(ω-3PUFA) can inhibit inflammation by some mechanisms namely,reducing metabolites from arachidonic acid(AA) by competing with it through a variety of ways,alteration of membrane lipid rafts,inhibition of nuclear receptor activation(specifically nuclear factor NF-κB)to modulate production of inflammatory mediators,and metabolism into novel pro-resolving and antiinflammatory mediators (resolvins and protectins).In addition,ω-3PUFA can reduce oxidative stress by improvement the antioxidant defense system,etc.Many clinical studies have demonstrated that ω-3PUF is effective in the for sepsis patients.The paper reviews the specific mechanism of ω-3PUFA treatment for sepsis.